{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:32:10Z","timestamp":1791595930409,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To assess whether the use of intravenous immunoglobulin (IVIG) in late\u2010preterm and term newborns with haemolytic disease of the newborn (HDN) is associated with an increased risk of necrotizing enterocolitis (NEC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective cohort study was conducted in a tertiary centre. Infants with HDN during early neonatal period (&lt;7\u2009days) who were of \u226534\u2009weeks' gestation and born between January 2019 and October 2021 were included. Propensity score, interaction as well as univariate and multiple logistic regression analyses were employed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010thousand two\u2010hundred and fifty\u2010nine infants with HDN were enrolled, of whom 192 (15.3%) received IVIG. NEC was diagnosed in 29 (2.3%) patients with 5 (2.6%) in the IVIG group and 24 (2.2%) in the non\u2010IVIG group. No significant association between IVIG administration and confirmed NEC was observed using univariate analysis (<jats:italic>p<\/jats:italic>\u00a0&gt;\u20090.05). The possible predictors of NEC, as assessed by multivariate analysis, were caesarean delivery, haemoglobin on admission &lt;130\u2009g\/L and patent ductus arteriosus (PDA). There was no interactive effect of IVIG against NEC for prematurity, low birth weight, caesarean delivery, haemoglobin on admission &lt;130\u2009g\/L and PDA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In late\u2010preterm and term infants with HDN, there was no evidence that the early use of IVIG led to the development of NEC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13297","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T01:19:08Z","timestamp":1653527948000},"page":"1098-1104","source":"Crossref","is-referenced-by-count":6,"title":["Is intravenous immunoglobulin a risk factor for necrotizing enterocolitis in neonates with haemolytic disease of the newborn? A retrospective cohort study"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-0644","authenticated-orcid":false,"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics Women and Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women and Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Jie","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women and Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Fan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women and Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women and Children's Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304878"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0676"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.718387"},{"key":"e_1_2_8_5_1","article-title":"Immunoglobulin for alloimmune hemolytic disease in neonates","volume":"3","author":"Zwiers C","year":"2018","journal-title":"Cochrane Database Syst 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