{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:07:44Z","timestamp":1769922464589,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016300","name":"Octapharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016300","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This sub\u2010study of the FIBRES trial sought to examine the patterns of ABO\u2010compatible cryoprecipitate administration and to identify adverse consequences of ABO\u2010incompatible cryoprecipitate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a post hoc analysis of data collected from the FIBRES randomized clinical trial comparing fibrinogen concentrate with cryoprecipitate in the treatment of bleeding related to hypofibrinogenemia after cardiac surgery. The primary outcome was the percentage of administered cryoprecipitate that was ABO\u2010compatible. Secondary outcomes were adverse events at 28\u2009days. A follow\u2010up survey was distributed to the FIBRES participating sites to examine the rationale behind the identified cryoprecipitate ABO\u2010matching practice patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 363 patients were included: 53 (15%) received ABO\u2010incompatible cryoprecipitate and 310 (85%) received ABO\u2010compatible cryoprecipitate. There was an increased incidence of post\u2010operative anaemia in the ABO\u2010incompatible group (15; 28.3%) in comparison to the ABO\u2010compatible (44; 14.2%) group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) at 28\u2009days, which was unrelated to haemolysis, without a significant difference in transfusion requirement. In the multivariable logistic regression models accounting for clustering by site, there was no observed statistically significant association between the administration of ABO\u2010incompatible cryoprecipitate and any other adverse outcomes. Nine out of 11 sites did not have a policy requiring ABO\u2010matched cryoprecipitate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This sub\u2010study demonstrated that most cryoprecipitate administered in practice is ABO\u2010compatible, despite the absence of guidelines or blood bank policies to support this practice. A signal towards increased risk of post\u2010operative anaemia may be explained by higher rates of urgent surgery (vs. elective) in the ABO\u2010incompatible group. Future studies should prospectively examine the impact of ABO\u2010compatible versus incompatible cryoprecipitate to conclusively establish if there is a meaningful clinical impact associated with the administration of ABO\u2010incompatible cryoprecipitate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13330","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T07:23:27Z","timestamp":1657092207000},"page":"1105-1111","source":"Crossref","is-referenced-by-count":4,"title":["Practice patterns of <scp>ABO\u2010matching<\/scp> for cryoprecipitate and patient outcomes after <scp>ABO\u2010compatible<\/scp> versus incompatible cryoprecipitate"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9180-436X","authenticated-orcid":false,"given":"Tyler","family":"Raycraft","sequence":"first","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Bartoszko","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Department of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital University Health Network  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyvan","family":"Karkouti","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Department of Anesthesia and Pain Management, Sinai Health System, Women's College Hospital University Health Network  Toronto Ontario Canada"},{"name":"Peter Munk Cardiac Centre University Health Network  Toronto Ontario Canada"},{"name":"Interdepartmental Division of Critical Care, Department of Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Institute for Health Policy, Management, and Evaluation University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie","family":"Callum","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine Kingston Health Sciences Centre and Queen's University  Kingston Ontario Canada"},{"name":"University of Toronto Quality in Utilization Education and Safety in Transfusion Research Program  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-9020","authenticated-orcid":false,"given":"Yulia","family":"Lin","sequence":"additional","affiliation":[{"name":"University of Toronto Quality in Utilization Education and Safety in Transfusion Research Program  Toronto Ontario Canada"},{"name":"Precision Diagnostics and Therapeutics Program Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.81849"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.03.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu158"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01948.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.162684"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16125"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15601"},{"key":"e_1_2_9_9_1","unstructured":"Canadian Blood Services.Results of Hospital Practice Survey \u2013 Group AB Cryoprecipitate. Blood.ca.2017. 1\u20133. Available from:https:\/\/professionaleducation.blood.ca\/en\/transfusion\/best\u2010practices\/blood\u2010utilization\u2010best\u2010practices\/group\u2010ab\u2010cryoprecipitate\u2010hospital"},{"key":"e_1_2_9_10_1","unstructured":"AABB [Internet].Primer of blood administration.2002[cited 2020 Aug 26]. Available from:www.aabb.org\/resources\/marketplace\/Documents\/Primer.pdf"},{"key":"e_1_2_9_11_1","unstructured":"Australian and New Zealand Society of Blood Transfusion [Internet].Guidelines for transfusion and immunohaematology laboratory practice.2016 rev Jan 2020 [cited 2020 Aug 26]. Available from:https:\/\/anzsbt.org.au\/wp\u2010content\/uploads\/2020\/03\/Guideline_\u2010for_Transfusion_and_Immunohaematology_Laboratory_Practice_20200326_FINAL_Published_SecurePW\u20101.pdf"},{"key":"e_1_2_9_12_1","unstructured":"American Red Cross [Internet].A compendium of transfusion practice guidelines.2021[cited 2022 Mar 13]. 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