{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:09:25Z","timestamp":1792343365994,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005866","name":"Far Eastern Memorial Hospital","doi-asserted-by":"publisher","award":["FEMH\u20102019\u2010C\u2010030"],"award-info":[{"award-number":["FEMH\u20102019\u2010C\u2010030"]}],"id":[{"id":"10.13039\/501100005866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Although it remains controversial, premedication before transfusion is a common clinical practice to prevent transfusion\u2010associated adverse reactions (TAARs) in Taiwan. Thus, we aimed to investigate whether premedication prevented outpatients from developing TAARs and whether an educational programme could improve the understanding of physicians related to the unnecessary use of premedication, and this could elicit changes in their prescribing activities without affecting the occurrence of TAARs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Clinical data from outpatients receiving transfusion therapy, including predisposing diseases, histories of transfusion and TAARs, premedication and the occurrence of TAARs in the period April 2017 to October 2018, were retrospectively obtained. The evidence\u2010based transfusion programme implemented to educate physicians was started in January 2018.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5018 blood units were transfused to 803 outpatients, with 2493 transfusion events reported in the study interval. The most frequently transfused component was leukocyte\u2010reduced packed red cells (<jats:italic>n<\/jats:italic>\u00a0=\u00a04338), followed by leukocyte\u2010reduced apheresis platelets (<jats:italic>n<\/jats:italic>\u00a0=\u00a0540) and other blood components. The overall premedication rate significantly decreased from 92.4% to 76.7% after the educational programme (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was no remarkable change in the occurrence of TAARs per patient event between the periods before and after the educational programme (1.11% vs. 1.14%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.964). Besides, it was shown that the occurrence of TAARs was associated with the history of TAARs and inversely related to multiple transfusions, but not premedication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased premedication was not associated with increased incidence of TAARs in outpatients; these findings provide important evidence to support the need to revise clinical practices in the era of leukocyte\u2010reduced blood products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13333","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T22:19:17Z","timestamp":1658096357000},"page":"1179-1186","source":"Crossref","is-referenced-by-count":3,"title":["The abrogated role of premedication in the prevention of transfusion\u2010associated adverse reactions in outpatients receiving leukocyte\u2010reduced blood components"],"prefix":"10.1111","volume":"117","author":[{"given":"Yuan\u2010Bin","family":"Yu","sequence":"first","affiliation":[{"name":"Division of Oncology and Hematology, Department of Internal Medicine Far Eastern Memorial Hospital  New Taipei Taiwan"},{"name":"Faculty of Medicine, School of Medicine National Yang Ming Chiao Tung University  Taipei Taiwan"},{"name":"Graduate Institute of Medicine Yuan Ze University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai\u2010Chen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Far Eastern Memorial Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yee","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Far Eastern Memorial Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Jung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Far Eastern Memorial Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Public Health Bureau  New Taipei Taiwan"},{"name":"Department of Nursing Cardinal Tien Junior College of Healthcare and Management  Yilan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-7026","authenticated-orcid":false,"given":"Chih\u2010Chun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Far Eastern Memorial Hospital  New Taipei Taiwan"},{"name":"Department of Nursing Cardinal Tien Junior College of Healthcare and Management  Yilan Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College 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