{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:14:15Z","timestamp":1789755255189,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The field of transfusion medicine started out with whole blood transfusion to treat severe anaemia and other deficiencies, and then transitioned to component therapy, largely leaving the practice, and experiences, of whole blood transfusions behind. Currently, the field is circling back and whole blood is gaining ground as an alternative to massive transfusion protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Herein we describe a severely anaemic paroxysmal nocturnal haemoglobinuria (PNH) patient initially suspected of suffering from renal haemorrhage, receiving a standard low\u2010titre group O whole blood transfusion during pre\u2010hospital transportation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following the transfusion, the patient suffered a clinically unmistakable haemolytic transfusion reaction requiring supportive treatment in the intensive care unit. Clinical observations are consistent with an acute haemolytic reaction. The haemolysis was likely due to minor incompatibility between the plasma from the transfused whole blood and the patient's PNH red cells. Recovery was uneventful.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This revealed an unappreciated contraindication to minor incompatible whole blood transfusion, and prompted a discussion on the distinction between whole blood and erythrocyte concentrates, the different indications for use and the importance of emphasizing these differences. It also calls attention to patient groups where minor incompatibility can be of major importance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13354","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T08:24:45Z","timestamp":1663143885000},"page":"1323-1326","source":"Crossref","is-referenced-by-count":6,"title":["Whole blood transfusion and paroxysmal nocturnal haemoglobinuria meet again: Minor incompatibility, major trouble"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-4018","authenticated-orcid":false,"given":"Ingvild Jenssen","family":"L\u00e6greid","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Division of Diagnostic services University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Prehospital services Finnmark Hospital Trust  Kirkenes Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer Hjert\u00f8","family":"N\u00e6ss","sequence":"additional","affiliation":[{"name":"Division of Prehospital services Finnmark Hospital Trust  Kirkenes Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9515-0922","authenticated-orcid":false,"given":"Siw Leiknes","family":"Ernstsen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Diagnostic services University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Schou","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Kirkenes Hospital, Finnmark Hospital Trust  Kirkenes Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana Grujic","family":"Arsenovic","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Diagnostic services University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2021.07.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/XCS.0000000000000086"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/emp2.12089"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02491-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15601"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15629"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-522128"},{"key":"e_1_2_7_9_1","first-page":"65","article-title":"Transfusion of saline\u2010washed red cells in nocturnal haemoglobinuria (Marchiafava\u2010Micheli disease)","volume":"7","author":"Dacie JV","year":"1948","journal-title":"Clin Sci"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29890020439.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1989.29890020434.x"},{"key":"e_1_2_7_12_1","first-page":"363","article-title":"Complement\u2010mediated haemolysis and the role of blood transfusion in paroxysmal nocturnal haemoglobinuria","volume":"13","author":"Olutogun T","year":"2015","journal-title":"Blood 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Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13354","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:03:25Z","timestamp":1692651805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/vox.13354"],"URL":"https:\/\/doi.org\/10.1111\/vox.13354","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]}}}