{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:11:43Z","timestamp":1783581103545,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Haemolytic disease of the newborn (HDN) is an immune haemolytic anaemia from maternal alloantibodies. Rh immunoglobulin (RhIg) prophylaxis can prevent alloimmunization to the D antigen. However, RhIg is not universally available in Uganda. ABO incompatibility also causes HDN. We determined the prevalence of HDN among newborn infants with jaundice in Uganda.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We conducted a prospective cross\u2010sectional study at Kawempe National Referral Hospital, Kampala, Uganda. Infants aged 0\u201314\u2009days with neonatal jaundice (or total bilirubin &gt;50\u2009\u03bcmol\/L) were enrolled. Clinical evaluation and laboratory testing, including ABO, RhD typing and maternal antibody screen, were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 466 babies were enrolled. The mean (SD) age was 3.4 (1.5) days. Of newborn babies with jaundice, 17.2% (80\/466) had HDN. Babies with HDN had lower haemoglobin (SD); 15.7 (2.7) compared with those without HDN; 16.4 (2.4) g\/dL, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016; and a higher bilirubin (interquartile range); 241 (200\u2013318) compared with those without HDN; 219 (191\u2013263) \u03bcmol\/L, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001. One baby had anti\u2010D HDN, while 46\/466 had HDN from an ABO incompatibility (anti\u2010A 43.5% and anti\u2010B 56.5%); 82% of babies with HDN also had suspected neonatal sepsis or birth asphyxia. About 79.2% (57\/72) of mothers did not have ABO\/Rh blood group performed antenatally. All infants with HDN survived except one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Among newborn infants with jaundice, HDN is not rare. The majority is due to ABO HDN affecting group A and group B babies equally. Ensuring routine ABO\/Rh grouping for all pregnant women is an area for improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13376","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T14:29:21Z","timestamp":1667831361000},"page":"1398-1404","source":"Crossref","is-referenced-by-count":4,"title":["A cross\u2010sectional study of haemolytic disease of the newborn in Uganda"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-3925","authenticated-orcid":false,"given":"Aggrey","family":"Dhabangi","sequence":"first","affiliation":[{"name":"Child Health and Development Centre Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolly","family":"Nankunda","sequence":"additional","affiliation":[{"name":"Department of Critical Care Mulago Specialized Women and Neonatal Hospital  Kampala Uganda"},{"name":"Department of Pediatric and Child Health Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violet","family":"Okaba","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Child Health Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Nakubulwa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Hume","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Montreal  Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter H.","family":"Dzik","sequence":"additional","affiliation":[{"name":"Department of Pathology, Blood Transfusion Service Harvard University and the Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Heddle","sequence":"additional","affiliation":[{"name":"McMaster University McMaster Centre for Transfusion Research  Hamilton Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"561","volume-title":"AABB technical manual","author":"Kennedy MS","year":"2014"},{"key":"e_1_2_8_3_1","first-page":"428","volume-title":"Modern blood banking and transfusion practice","author":"Harmening DM","year":"2012"},{"key":"e_1_2_8_4_1","first-page":"291","volume-title":"AABB technical manual","author":"Cooling L","year":"2014"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12265"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60651-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16061"},{"key":"e_1_2_8_8_1","first-page":"29","article-title":"Incidence of hemolytic disease of the newborn in Harare, Zimbabwe","volume":"27","author":"Mandisodz AR","year":"2008","journal-title":"West Afr J Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.02.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000109206.22354.2C"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000149153.93417.66"},{"key":"e_1_2_8_12_1","unstructured":"Kawempe National Referral Hospital.Hospital registry2019."},{"key":"e_1_2_8_13_1","unstructured":"Determining sample size based on confidence and margin of error. 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