{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:48:10Z","timestamp":1763621290360,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Immune\u2010mediated acute or delayed transfusion reactions occur when there is immunological incompatibility between transfused blood products and recipient's antibodies. Acute haemolytic transfusion reactions occur within 24\u2009h and are delayed after 24\u2009h up to 10\u2009days following transfusion, whereas post\u2010transfusion purpura (PTP) typically occurs 7\u201310\u2009days post\u2010transfusion. We present a case of a previously transfused and recently post\u2010partum female who developed both delayed haemolytic transfusion reaction (DHTR) and PTP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 42\u2010year\u2010old woman, G2P1, with non\u2010alcoholic liver disease, portal hypertension and previous transfusion history with allogeneic anti\u2010E, developed a severe DHTR and PTP following a complicated post\u2010partum course and multiple transfusions. The antenatal and initial post\u2010partum pre\u2010transfusion antibody screens were negative. Subsequently five red cell antibodies, including anti\u2010c, anti\u2010Fya, anti\u2010Jkb and anti\u2010S and the reappearance of anti\u2010E were, however, identified during follow\u2010up investigations along with the anti\u2010platelet antibody HPA\u20103a and human leukocyte antigen class I antibodies. Anti\u2010E, anti\u2010Jkb and anti\u2010S were eluted from the circulating red blood cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, there have been only two other case reports of DHTR and PTP occurring in the same patient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13381","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T15:25:20Z","timestamp":1669389920000},"page":"98-103","source":"Crossref","is-referenced-by-count":1,"title":["The complexities of transfusion reactions: Coexistence of a delayed haemolytic transfusion reaction and post\u2010transfusion purpura"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2599-8407","authenticated-orcid":false,"given":"Joanna","family":"Czerwinski","sequence":"first","affiliation":[{"name":"Department of Haematology, Division of Medicine Flinders Medical Centre  Bedford Park Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-5625","authenticated-orcid":false,"given":"Ana","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Obstetric Medicine, Division of Medicine Northern Adelaide Local Health Network, Lyell McEwin Hospital  Elizabeth Vale Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8532-7843","authenticated-orcid":false,"given":"Denise","family":"Herbert","sequence":"additional","affiliation":[{"name":"Immunogenetics Laboratory Victorian Transplantation and Immunogenetics Service (VTIS)  West Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-3832","authenticated-orcid":false,"given":"David","family":"Roxby","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Pathology (Haematology\/Transfusion Medicine), College of Medicine and Public Health Flinders University  Bedford Park Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-8396","authenticated-orcid":false,"given":"Magdalena","family":"Sobieraj\u2010Teague","sequence":"additional","affiliation":[{"name":"Department of Haematology, Division of Medicine Flinders Medical Centre  Bedford Park Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"U.S. Centers for Disease Control and Prevention.National Healthcare Safety Network Biovigilance Component Hemovigilance Module Surveillance Protocol.2021. Available from:https:\/\/www.cdc.gov\/nhsn\/pdfs\/biovigilance\/bv-hv-protocol-current.pdf."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1309\/NED8-F1HQ-JUJR-A34T"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S189176"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1993.tb00062.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01729839"},{"key":"e_1_2_10_7_1","first-page":"175","article-title":"Post\u2010transfusion purpura","volume":"4","author":"Vincent EC","year":"1991","journal-title":"J Am Board of Fam Pract"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8187659"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199607)52:3<205::AID-AJH13>3.0.CO;2-E"},{"key":"e_1_2_10_10_1","unstructured":"Australian Red Cross Lifeblood.Delayed Haemolytic Transfusion Reactions (DHTR).2022[updated 2021\u20132022]. Available from:https:\/\/www.lifeblood.com.au\/health-professionals\/clinical-practice\/adverse-events\/DHTR."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24414"},{"key":"e_1_2_10_12_1","first-page":"e1207","article-title":"Post\u2010transfusion purpura: a case report of an underdiagnosed phenomenon","volume":"9","author":"Rafei H","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_10_13_1","unstructured":"Australian Red Cross Lifeblood.Red cell compatibility calculator.2021\u20132022. Available from:https:\/\/www.lifeblood.com.au\/health-professionals\/testing\/red-cell-compatibility-calculator."}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13381","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13381","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T14:20:50Z","timestamp":1692454850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/vox.13381"],"URL":"https:\/\/doi.org\/10.1111\/vox.13381","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"type":"print","value":"0042-9007"},{"type":"electronic","value":"1423-0410"}],"subject":[],"published":{"date-parts":[[2022,11,25]]}}}