{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:09:43Z","timestamp":1789697383929,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","award":["1931F"],"award-info":[{"award-number":["1931F"]}],"id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Transfusion\u2010associated circulatory overload (TACO) is a pulmonary transfusion complication and a leading cause of transfusion\u2010related morbidity and mortality. Volume overload and rising hydrostatic pressure as a consequence of transfusion are seen as the central pathway leading to TACO. A possible preventative measure for TACO could be the use of low\u2010volume blood products like volume\u2010reduced lyophilized plasma. We hypothesize that volume\u2010reduced lyophilized plasma decreases circulatory overload leading to a reduced pulmonary capillary pressure and can therefore be an effective strategy to prevent TACO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A validated two\u2010hit animal model in rats with heart failure was used. Animals were randomized to receive 4\u2009units of either solvent\u2010detergent pooled plasma (SDP) as control, standard volume lyophilized plasma (LP\u2010S) or hyperoncotic volume\u2010reduced lyophilized plasma (LP\u2010VR). The primary outcome was the difference between pre\u2010transfusion and post\u2010transfusion left ventricular end\u2010diastolic pressure (\u0394LVEDP). Secondary outcomes included markers for acute lung injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LVEDP increased in all randomization groups following transfusion. The greatest elevation was seen in the group receiving LP\u2010VR (+11.9\u2009mmHg [5.9\u201315.6]), but there were no significant differences when compared to groups receiving either LP\u2010S (+6.3\u2009mmHg [2.9\u201313.4], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.29) or SDP (+7.7\u2009mmHg [4.5\u201310.5], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.55). There were no significant differences in markers for acute lung injury, such as pulmonary wet\/dry weight ratios, lung histopathology scores or PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio between the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transfusion with hyperoncotic volume\u2010reduced plasma did not attenuate circulatory overload compared to standard volume plasma and was therefore not an effective preventative strategy for TACO in this rat model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13395","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T02:33:25Z","timestamp":1672886005000},"page":"185-192","source":"Crossref","is-referenced-by-count":6,"title":["Can volume\u2010reduced plasma products prevent transfusion\u2010associated circulatory overload in a two\u2010hit animal model?"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1578-2813","authenticated-orcid":false,"given":"Esther B.","family":"Bulle","sequence":"first","affiliation":[{"name":"Department of Intensive Care Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-4530","authenticated-orcid":false,"given":"Robert B.","family":"Klanderman","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Anesthesiology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit B.","family":"de Wissel","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Intensive Care and Anesthesiology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris J. T. H.","family":"Roelofs","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Microcirculation University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise P.","family":"Veelo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charissa E.","family":"van den Brom","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Anesthesiology Amsterdam UMC, VU University  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Kapur","sequence":"additional","affiliation":[{"name":"Sanquin Research, Department of Experimental Immunohematology Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander P. J.","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology Amsterdam UMC, University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15389"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000513"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.07.002"},{"key":"e_1_2_8_5_1","unstructured":"NarayanS Poles eaD. on behalf of theSerious Hazards of Transfusion (SHOT) Steering Group.The 2021 Annual SHOT Report. 2022. [cited 2022 Dec 5]. Available from:https:\/\/www.shotuk.org\/shot-reports"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14432"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-860809"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100891"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnc.2017.04.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001506"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002948"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13929"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000411"},{"key":"e_1_2_8_15_1","article-title":"The effect of plasma transfusion in an experimental two\u2010hit animal model of transfusion\u2010associated circulatory overload with heart failure","author":"Bulle EB","year":"2022","journal-title":"Blood Transfus"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.26.759"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13191"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15565"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.32.1.99"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.138"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12932"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer515"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201405-0850OC"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.01.003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.7.4.649"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000002719"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182329210"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02748.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-04-0266"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:06:26Z","timestamp":1692648386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/vox.13395"],"URL":"https:\/\/doi.org\/10.1111\/vox.13395","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]}}}