{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:58:32Z","timestamp":1792418312753,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Clinicians sought to ascertain what frequency of vital signs best detects blood transfusion reactions. This review discusses early and delayed blood product transfusion reaction detection through the lens of scientific literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive appraisal of published literature was conducted using Integrative Research Review methodology through June 2022 not limited to English or research in Cumulative Index to Nursing and Allied Health Literature, Cochrane Library of Systematic Reviews, Medline and PubMed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Full\u2010text articles in the final sample included four articles discussing vital signs detecting blood transfusion reactions and four articles reporting the importance of adding physical assessments for early reaction detection. None of the studies provided evidence regarding how often vital signs should be monitored to detect transfusion reactions. No studies included identical screening components for detecting blood product transfusion reactions. Main themes emerged including variations in what was included in vital signs, importance of respiratory assessment, inclusion of physical assessment, nurse documentation and reporting compliance, and patient and family inclusion in transfusion reaction recognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vital sign components varied across reviewed studies. Respiratory rate and pain were not always included in \u2018vital signs\u2019 to identify transfusion reactions. Only low\u2010level data and no clinical trials loosely informing frequency of vital sign monitoring to transfusion reaction detection were found. Respiratory (to include oxygen saturation, lung sounds and respiratory rate) and pain assessment emerged as crucial to acute and delayed transfusion reaction recognition. The disconnect between \u2018vital signs\u2019 and the varied vital sign components reported to detect transfusion reactions in scientific literature requires further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13396","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T17:00:36Z","timestamp":1672074036000},"page":"109-120","source":"Crossref","is-referenced-by-count":9,"title":["Should adding pain, oxygen saturation and physical assessment to vital signs become the new standard of care for detecting blood transfusion reactions?"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-4657","authenticated-orcid":false,"given":"Jamie Kay","family":"Roney","sequence":"first","affiliation":[{"name":"Nursing Administration Covenant Health  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Erin","family":"Whitley","sequence":"additional","affiliation":[{"name":"Covenant School of Nursing Covenant Health  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Johnston","sequence":"additional","affiliation":[{"name":"Staffing Operations Office Covenant Medical Center  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michella","family":"Deleon","sequence":"additional","affiliation":[{"name":"Patient Placement Coordination Center Covenant Medical Center  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith Christine","family":"Robnett","sequence":"additional","affiliation":[{"name":"Hydrotherapy Service Covenant Medical Center  Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12310"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1188\/15.CJON.516-520"},{"key":"e_1_2_9_4_1","first-page":"89","article-title":"Blood transfusion vital sign frequency: what does the evidence say?","volume":"26","author":"Cortez\u2010Gann J","year":"2017","journal-title":"Medsurg Nurs"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1188\/13.CJON.543-545"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12621"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nuf.12697"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15931"},{"key":"e_1_2_9_9_1","unstructured":"Fatalities reported to FDA following blood collection and transfusion: Annual summary for the Fiscal Year 2018. Federal Drug Administration. Available from:https:\/\/www.fda.gov\/media\/136907\/download."},{"key":"e_1_2_9_10_1","first-page":"88","article-title":"Early identification of acute hemolytic transfusion reactions: Realistic implications for best practice in patient monitoring","volume":"25","author":"Menendez JB","year":"2016","journal-title":"Medsurg Nurs"},{"key":"e_1_2_9_11_1","first-page":"8","article-title":"Accent on research DATA BITS: assess. check. Repeat: examining the evidence of blood transfusion vital sign frequency","volume":"66","author":"French M","year":"2018","journal-title":"Ky Nurse"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1750458916024001-203"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2648.2005.03621.x"},{"key":"e_1_2_9_14_1","first-page":"429","volume-title":"Evidence\u2010based nursing: the research\u2010practice connection","author":"Brown SJ","year":"2012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2021.03.001"},{"key":"e_1_2_9_16_1","unstructured":"EQUATOR network: Enhancing the quality and transparency of health research. [Cited 2019 May 29]. Available from:http:\/\/www.equator-network.org\/."},{"key":"e_1_2_9_17_1","volume-title":"Nursing research: generating and assessing evidence for nursing practice","author":"Polit D","year":"2016"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000235"},{"key":"e_1_2_9_19_1","first-page":"103","article-title":"Avalia\u00e7\u00e3o dos registros de enfermagem em hemoterapia de um hospital geral","volume":"31","author":"Paiva dos Santos S","year":"2013","journal-title":"Avances en Enfermer\u00eda"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000738"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/10903127.2016.1142624"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13060"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481608200730"},{"key":"e_1_2_9_24_1","first-page":"5","article-title":"DVA names pain the 5th vital sign","volume":"9","author":"Kirk L","year":"2000","journal-title":"ASPMN Pathways"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.4.423b"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5832"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16362"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13396","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T16:42:09Z","timestamp":1692376929000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/vox.13396"],"URL":"https:\/\/doi.org\/10.1111\/vox.13396","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,26]]}}}