{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:45:48Z","timestamp":1787683548470,"version":"build-2784847793"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Serum eye drops (SEDs) are used to treat ocular surface disease (OSD) and to promote ocular surface renewal. However, their use and production are not standardized, and several new forms of human eye drops have been developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The International Society for Blood Transfusion Working Party (ISBT WP) for Cellular Therapies held a workshop to review the current types\u00a0of\u00a0eye drops of human origin (EDHO) status and provide guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ISBT WP for Cellular Therapies introduced the new terminology \u2018EDHO\u2019 to emphasize that these products are analogous to \u2018medical products of human origin\u2019. This concept encompasses their source (serum, platelet lysate, and cord\u00a0blood) and the increasingly diverse spectrum of clinical usage in ophthalmology and the need for traceability. The workshop identified the wide variability in EDHO manufacturing, lack of harmonized quality and production standards, distribution issues, reimbursement schemes and regulations. EDHO use and efficacy is established for the treatment of OSD, especially for those refractory to conventional treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Production and distribution of single\u2010donor donations are cumbersome and complex. The workshop participants agreed that allogeneic EDHO have advantages over autologous EDHO although more data on clinical efficacy and safety are needed. Allogeneic EDHOs enable more efficient production and, when pooled, can provide enhanced standardization for clinical consistency, provided optimal margin of virus safety is ensured. Newer products, including platelet\u2010lysate\u2010 and cord\u2010blood\u2010derived EDHO, show promise and benefits over SED, but their safety and efficacy are yet to be fully established. This workshop highlighted the need for harmonization of EDHO standards and guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13413","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T11:29:05Z","timestamp":1677497345000},"page":"301-309","source":"Crossref","is-referenced-by-count":14,"title":["Eye drops of human origin\u2014Current status and future needs: Report on the workshop organized by the <scp>ISBT<\/scp> Working Party for Cellular Therapies"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-9320","authenticated-orcid":false,"given":"Christian","family":"Gabriel","sequence":"first","affiliation":[{"name":"Department of Blood Group Serology and Transfusion Medicine Medical University of Graz  Graz Austria"},{"name":"Ludwig Boltzmann Institute for Clinical and Experimental Traumatology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-6934","authenticated-orcid":false,"given":"Denese C.","family":"Marks","sequence":"additional","affiliation":[{"name":"Research and Development The Australian Red Cross Lifeblood  Sydney Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5895-4259","authenticated-orcid":false,"given":"Reinhard","family":"Henschler","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine University Hospital and Medical Faculty, University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-0058","authenticated-orcid":false,"given":"Katharina","family":"Schallmoser","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI\u2010TReCS) Paracelsus Medical University (PMU)  Salzburg Austria"},{"name":"Department of Blood Group Serology and Transfusion Medicine Universit\u00e4tsklinikum, Salzburger Landeskliniken GesmbH (SALK)  Salzburg Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0507-9243","authenticated-orcid":false,"given":"Thierry","family":"Burnouf","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering Taipei Medical University  Taipei Taiwan"},{"name":"International PhD Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-2502","authenticated-orcid":false,"given":"Mickey B. 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