{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:40:53Z","timestamp":1787683253808,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transfusion medicine resembles all of medicine in that expert opinion predominates because hard data on clinical outcomes from randomized controlled trials and high quality observational data are simply unavailable. Indeed, some of the first trials evaluating important outcomes are barely two decades old. Patient blood management (PBM) depends on high quality data for assisting clinicians in making clinical decisions. In this review, we focus on several red blood cell (RBC) transfusion practices that new data suggest need reconsideration. The practices that may need revision include transfusion for iron deficiency anaemia, except in life threatening situations, toleration of anaemia as a largely benign condition and use of haemoglobin\/haematocrit as primary indications for RBC transfusion, as opposed to adjuncts to clinical judgement. In addition, the long\u2010standing notion that the minimum transfusion should be two units needs to be abandoned due to the danger to patients and a lack of clinical evidence of benefit. Finally, the difference in indications for leucoreduction versus irradiation needs to be understood by all practitioners. PBM is one of the strategies for managing anaemia and bleeding that holds great promise for patients, and transfusion is only one facet of the bundle of practices.<\/jats:p>","DOI":"10.1111\/vox.13442","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T10:11:30Z","timestamp":1684750290000},"page":"509-516","source":"Crossref","is-referenced-by-count":7,"title":["Patient blood management: Myths and facts about red blood cell transfusions"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1175-9579","authenticated-orcid":false,"given":"Richard R.","family":"Gammon","sequence":"first","affiliation":[{"name":"OneBlood, Scientific, Medical, Technical Direction  Orlando Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-5652","authenticated-orcid":false,"given":"Neil","family":"Blumberg","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine University of Rochester Medical Center  Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Gilstad","sequence":"additional","affiliation":[{"name":"Transfusion Service Medstar Georgetown University Hospital  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-5295","authenticated-orcid":false,"given":"Saikat","family":"Mandal","sequence":"additional","affiliation":[{"name":"University Hospital Southampton NHS Foundation Trust  Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita Radhakrishnan","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Sree Chitra Tirunal Institute for Medical Sciences and Technology  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Bocquet","sequence":"additional","affiliation":[{"name":"Association for the Advancement of Blood and Biotherapies  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15604"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13735"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2021.04.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13327"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12968"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199310000-00002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1801869"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.18.00697"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03154.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2022.103397"},{"key":"e_1_2_6_12_1","volume-title":"Archived: iron deficiency anaemia: assessment, prevention and control","author":"World Health Organization","year":"2001"},{"key":"e_1_2_6_13_1","volume-title":"Four tests and treatment to questions in perinatal transfusion medicine","year":"2020"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43678-021-00082-2"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/cem.2016.388"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.01010.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496965"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14819"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13773"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.10.007"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14626"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453310X12583347010052"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12875-017-0647-8"},{"key":"e_1_2_6_24_1","volume-title":"The urgent need to implement patient blood management: policy brief","author":"World Health Organization","year":"2021"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.04.089"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14006"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002397"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0554"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2013.849335"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12396"},{"key":"e_1_2_6_31_1","volume-title":"Hematology: Basic Principles and Practice","author":"Ness PM","year":"2005"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-4-199408150-00009"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16238"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.047035"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13211"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.07.007"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12802"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16338"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16789"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470692233"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-194209000-00032"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(55)90219-9"},{"key":"e_1_2_6_43_1","volume-title":"Blood transfusion in clinical medicine","author":"Mollison P","year":"2007"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01614-w"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1956.02970090010003"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34594249050.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211801"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01465.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1961.tb00318.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800565"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06981-9.50017-X"},{"key":"e_1_2_6_52_1","volume-title":"Standards for blood banks and transfusion services","author":"Gammon R","year":"2022"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03018302"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01158.x"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.08.063"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813726-0.00042-8"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-620872"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T20:27:08Z","timestamp":1692217628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/vox.13442"],"URL":"https:\/\/doi.org\/10.1111\/vox.13442","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]}}}