{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T12:57:20Z","timestamp":1771333040921,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["101015756"],"award-info":[{"award-number":["101015756"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>There is a need for conversion of SARS\u2010CoV\u20102 serology data from different laboratories to a harmonized international unit. We aimed to compare the performance of multiple SARS\u2010CoV\u20102 antibody serology assays among 25 laboratories across 12 European countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>To investigate this we have distributed to all participating laboratories a panel of 15 SARS\u2010CoV\u20102 plasma samples and a single batch of pooled plasma calibrated to the WHO IS 20\/136 standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All assays showed excellent discrimination between SARS\u2010CoV\u20102 seronegative plasma samples and pre\u2010vaccinated seropositive plasma samples but differed substantially in raw antibody titres. Titres could be harmonized to binding antibody units per millilitre by calibration in relation to a reference reagent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The standardization of antibody quantification is of paramount importance to allow interpretation and comparison of serology data reported in clinical trials in order to identify donor cohorts from whom the most effective convalescent plasma can be collected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13480","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T08:20:35Z","timestamp":1688458835000},"page":"666-673","source":"Crossref","is-referenced-by-count":8,"title":["Quality assessment and harmonization of laboratories across Europe for multiple <scp>SARS\u2010CoV<\/scp>\u20102 serology assays"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1322-5869","authenticated-orcid":false,"given":"Maurice","family":"Steenhuis","sequence":"first","affiliation":[{"name":"Department of Immunopathology Sanquin Research and Landsteiner Laboratory Academic Medical Centre  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Wouters","sequence":"additional","affiliation":[{"name":"Transfusion Research Center Belgian Red Cross Flanders  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Schrezenmeier","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine Ulm University  Ulm Germany"},{"name":"Institute for Clinical Transfusion Medicine and Immunogenetics German Red Cross Blood Transfusion Service Baden\u2010Wurttemberg\u2010Hessen and University Hospital Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo","family":"Rispens","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Sanquin Research and Landsteiner Laboratory Academic Medical Centre  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-8322","authenticated-orcid":false,"given":"Pierre","family":"Tiberghien","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang  La Plaine St\u2010Denis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Harvala","sequence":"additional","affiliation":[{"name":"Microbiology Services NHS Blood and Transplant  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-8852","authenticated-orcid":false,"given":"Hendrik B.","family":"Feys","sequence":"additional","affiliation":[{"name":"Transfusion Research Center Belgian Red Cross Flanders  Ghent Belgium"},{"name":"Department of Diagnostic Sciences Ghent University  Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Ellen","family":"van der Schoot","sequence":"additional","affiliation":[{"name":"Department of Immunopathology Sanquin Research and Landsteiner Laboratory Academic Medical Centre  Amsterdam Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SUPPORT\u2010E Collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(21)00266-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00989-21"},{"key":"e_1_2_9_4_1","article-title":"Establishment of the 2nd WHO International Standard for anti\u2010SARS\u2010CoV\u20102 immunoglobulin and Reference Panel for antibodies to SARS\u2010CoV\u20102 variants of concern","volume":"2427","author":"Bentley EM","year":"2022","journal-title":"World Heal Organ"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138745"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI152264"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.08.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.18178"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06829-7"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29911-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13060"},{"key":"e_1_2_9_13_1","first-page":"277","article-title":"Position paper on the use of COVID\u201019 convalescent plasma: an update","volume":"19","author":"Prati D","year":"2021","journal-title":"Blood Transfus"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01488-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.27.2100568"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02005-20"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12746"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1285"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2021.08.024"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04778-y"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:33:38Z","timestamp":1692423218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":19,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/vox.13480"],"URL":"https:\/\/doi.org\/10.1111\/vox.13480","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,4]]}}}