{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:42:17Z","timestamp":1781707337327,"version":"3.54.5"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>This systematic review update summarizes evidence concerning transfusion\u2010transmissible infections (TTIs) in male blood donors reporting sex with another man (MSM) or after easing the MSM deferral period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We searched five databases, including studies comparing MSM versus non\u2010MSM donors (Type I), MSM deferral periods (Type II) or infected versus non\u2010infected donors (Type III) in Western countries, and used GRADE to determine evidence certainty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five observational studies were included. Four Type I studies suggest that there may be an increased risk for overall TTIs, human immunodeficiency virus (HIV), hepatitis B virus (HBV) and syphilis in MSM donors, but the evidence is very uncertain. There was insufficient evidence of MSM with low\u2010risk sexual behaviour. A Type II study indicates that easing the MSM deferral period to 1\u2009year may have little to no effect on TTI risk. TTI prevalence in blood donors under 5\u2010year, 1\u2010year, 3\u2010month or risk\u2010based deferral in eight other Type II studies was too low to provide clear conclusions on the effect of easing the deferral. Three Type III studies reported that MSM may be a risk factor for HIV. Increased risk of HBV, hepatitis C virus and HTLV\u2010I\/II could not be shown. The evidence from Type III studies is very uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There may be an increased risk of HIV in MSM blood donors. Shortening the deferral from permanent to 1\u2009year may have little to no effect on TTI risk. However, there is limited, unclear evidence from observational studies concerning the impact of introducing 3\u2010month or risk\u2010based deferrals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13482","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T04:30:09Z","timestamp":1686889809000},"page":"709-720","source":"Crossref","is-referenced-by-count":4,"title":["Men who have sex with men and risk for transfusion\u2010transmissible infections in blood donors in Western countries: A systematic review update"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3108-584X","authenticated-orcid":false,"given":"Natalie","family":"Schroyens","sequence":"first","affiliation":[{"name":"Centre for Evidence\u2010Based Practice Belgian Red Cross  Mechelen Belgium"},{"name":"Department of Public Health and Primary Care, Leuven Institute for Healthcare Policy KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vere","family":"Borra","sequence":"additional","affiliation":[{"name":"Centre for Evidence\u2010Based Practice Belgian Red Cross  Mechelen Belgium"},{"name":"Department of Public Health and Primary Care, Leuven Institute for Healthcare Policy KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Compernolle","sequence":"additional","affiliation":[{"name":"Belgian Red Cross, Blood Services  Mechelen Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Ghent  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Vandekerckhove","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care, Leuven Institute for Healthcare Policy KU Leuven  Leuven Belgium"},{"name":"Belgian Red Cross  Mechelen Belgium"},{"name":"Division of Epidemiology and Biostatistics, Department of Global Health, Faculty of Medicine and Health Sciences Stellenbosch University  Stellenbosch South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-9781","authenticated-orcid":false,"given":"Emmy","family":"De Buck","sequence":"additional","affiliation":[{"name":"Centre for Evidence\u2010Based Practice Belgian Red Cross  Mechelen Belgium"},{"name":"Department of Public Health and Primary Care, Leuven Institute for Healthcare Policy KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"441","article-title":"Changing blood donor screening criteria from permanent deferral for men who have sex with men to individual sexual risk assessment: no evidence of a significant impact on the human immunodeficiency virus epidemic in Italy","volume":"11","author":"Suligoi B","year":"2013","journal-title":"Blood Transfus"},{"key":"e_1_2_8_3_1","unstructured":"FAIR.Can donor selection policy move from a population\u2010based donor selection policy to one based on a more individualized risk assessment? 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