{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:19:45Z","timestamp":1777504785742,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Bone marrow (BM) harvesting is one of the essential sources of stem cells for haematopoietic stem cell transplantation. In 2019, commercial BM collection kits became unavailable in Europe. Consequently, we created an in\u2010house BM collection kit as an alternative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We compared two groups of BM collections. The first collections were taken using an in\u2010house kit from June 2022 through February 2023 and the second with a commercial kit from February 2021 through May 2022. These all took place at seven collection centres (CC). We analysed the harvest quality (cell blood count, CD34+ cells, viability, potency and sterility), the incidents occurring with each kit and the time to neutrophil and platelet engraftment in recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 23 donors underwent BM harvesting with the in\u2010house kit and 23 with the commercial one. Both cohorts were comparable regarding donor characteristics, CC and time to procedure. No statistical differences were found in harvest quality between the in\u2010house and commercial kits. A new transfusion set was required in three BM harvests (13%) with the in\u2010house kit because of filter clogging. The median time to neutrophil and platelet engraftment was 21\u2009days for both cohorts and 29\u2009days (in\u2010house) and 33\u2009days (commercial), <jats:italic>p<\/jats:italic>\u2009=\u20090.284, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The in\u2010house BM collection kit offers a real approach to solve the diminished supply of commercial kits. A higher risk of filter clogging was observed compared with commercial kits due to the lack of 850 and 500\u2009\u03bcm filters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13499","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T04:36:49Z","timestamp":1691037409000},"page":"783-789","source":"Crossref","is-referenced-by-count":3,"title":["Development of an in\u2010house bone marrow collection kit: The Catalan bone marrow transplantation group experience"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4016-0020","authenticated-orcid":false,"given":"Jesus","family":"Fernandez\u2010Sojo","sequence":"first","affiliation":[{"name":"Advanced &amp; Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"},{"name":"Transfusion Medicine Group, Vall d'Hebron Institut de Recerca (VHIR) Vall d'Hebron Hospital Universitari  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Valdivia","sequence":"additional","affiliation":[{"name":"Advanced &amp; Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Esquirol","sequence":"additional","affiliation":[{"name":"Adult Haematology Department, Hospital de la Santa Creu i Sant Pau, IIB\u2010Sant Pau and Jose Carreras Leukaemia Research Institute Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose\u2010Manuel","family":"Portos","sequence":"additional","affiliation":[{"name":"Adult Haematology Department, Hospital de la Santa Creu i Sant Pau, IIB\u2010Sant Pau and Jose Carreras Leukaemia Research Institute Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Rovira","sequence":"additional","affiliation":[{"name":"BMT Unit, Haematology Department, Hospital Cl\u00ednic, IDIBAPS University of Barcelona, Josep Carreras Foundation and Leukaemia Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Suarez","sequence":"additional","affiliation":[{"name":"BMT Unit, Haematology Department, Hospital Cl\u00ednic, IDIBAPS University of Barcelona, Josep Carreras Foundation and Leukaemia Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Diaz\u2010de\u2010Heredia","sequence":"additional","affiliation":[{"name":"Paediatric Oncology and Haematology Department, Hospital Universitari Vall d'Hebron Vall d'Hebron Institute of Research (VHIR)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria\u2010Luz","family":"Ur\u00eda","sequence":"additional","affiliation":[{"name":"Paediatric Oncology and Haematology Department, Hospital Universitari Vall d'Hebron Vall d'Hebron Institute of Research (VHIR)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Ort\u00ed","sequence":"additional","affiliation":[{"name":"Adult Haematology Department Hospital Universitari Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Ferra","sequence":"additional","affiliation":[{"name":"Adult Haematology Department Institut Catal\u00e0 d'Oncologia\u2010Badalona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Mussetti","sequence":"additional","affiliation":[{"name":"Adult Haematology Department, Institut Catala d'Oncologia\u2010Hospitalet Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Paviglianiti","sequence":"additional","affiliation":[{"name":"Adult Haematology Department, Institut Catala d'Oncologia\u2010Hospitalet Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Marsal","sequence":"additional","affiliation":[{"name":"Paediatric SCT Unit, Haematology Department Hospital Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Badell","sequence":"additional","affiliation":[{"name":"Paediatric Haematology Department Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-833X","authenticated-orcid":false,"given":"Miquel","family":"Lozano","sequence":"additional","affiliation":[{"name":"Apheresis &amp; Cellular Therapy Unit, Department of Haemotherapy and Haemostasis ICMHO, Hospital Cl\u00ednic, IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gomez","sequence":"additional","affiliation":[{"name":"Advanced &amp; Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Azqueta","sequence":"additional","affiliation":[{"name":"Advanced &amp; Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lluis","family":"Martorell","sequence":"additional","affiliation":[{"name":"Advanced &amp; Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Rubio","sequence":"additional","affiliation":[{"name":"Advanced &amp; Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Garcia\u2010Buendia","sequence":"additional","affiliation":[{"name":"Statistical Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Villa","sequence":"additional","affiliation":[{"name":"Spanish Bone Marrow Donor Registry Josep Carreras Foundation and Leukaemia Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Carreras","sequence":"additional","affiliation":[{"name":"Spanish Bone Marrow Donor Registry Josep Carreras Foundation and Leukaemia Research Institute  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Querol","sequence":"additional","affiliation":[{"name":"Advanced &amp; Cell Therapy Services Banc de Sang i Teixits  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-022-01691-w"},{"key":"e_1_2_9_3_1","unstructured":"EBMT.Transplant activity survey 2022 summary. [cited 2022 Dec 17]. Available from:https:\/\/www.ebmt.org\/registry\/transplant-activity-survey"},{"key":"e_1_2_9_4_1","unstructured":"European Union.Regulation EU 2017\/745 on medical devices (medical device regulation MDR). [cited 2022 Dec 17]. Available from:https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/PDF\/?uri=CELEX:32017R0745"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102785"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V36.4.507.507"},{"key":"e_1_2_9_7_1","first-page":"78","volume-title":"Manual de Trasplante hematopoy\u00e9tico y terapia celular","author":"Rovira R","year":"2022"},{"key":"e_1_2_9_8_1","unstructured":"EBMT.Cellular therapy forms manual. [cited 2022 Dec 17]. Available from:https:\/\/www.ebmt.org\/sites\/default\/files\/2022-06\/Final%20Registry%2063_Cellular%20Therapy%20Forms%20Manual%20%28Castor%29_v1.0%20with%20footer.pdf"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2022.08.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12929"},{"key":"e_1_2_9_11_1","first-page":"294","volume-title":"Cellular therapy: principles, methods, and regulations","author":"Spitzer TR","year":"2016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.01.034"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.06.011"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705731"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240701420427"},{"key":"e_1_2_9_16_1","unstructured":"Fresenius Kabi.Bone marrow collection kit. [cited 2022 Dec 17]. Available from:https:\/\/www.fresenius-kabi.com\/kr\/documents\/Bone_Marrow_Collection_Kit_-_Product_Folder.pdf"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13499","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T02:52:13Z","timestamp":1714963933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/vox.13499"],"URL":"https:\/\/doi.org\/10.1111\/vox.13499","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]}}}