{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:47:07Z","timestamp":1791499627855,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Blood donor variability can affect the storage properties of packed red blood cells (PRBCs). This study aimed to determine the association of donor characteristics with in vitro storage haemolysis of PRBCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In the prospective observational study, a total of 109 whole blood donors were enrolled using the purposive sampling method. A pre\u2010donation sample was collected for haemoglobin (Hb) and serum uric acid (UA) levels. PRBC aliquots were tested for potassium, lactate dehydrogenase (LDH), Hb, haematocrit, plasma Hb and haemolysis on days 1, 21 and 35 of storage. The association of these parameters with donor age, sex, donation status, dietary pattern and body mass index was determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean haemolysis was significantly higher in PRBCs from donors with UA levels \u22646\u2009mg\/dL than donors with UA levels &gt;6\u2009mg\/dL on day 35 of storage (0.22\u2009\u00b1\u20090.11 vs. 0.18\u2009\u00b1\u20090.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Median plasma Hb (mg\/L) was significantly higher in PRBCs from first\u2010time donors on day 21 (586 vs. 509, <jats:italic>p<\/jats:italic>\u2009=\u20090.05) and day 35 (1507 vs. 1358, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) of storage in comparison to frequent donors. Significantly higher mean potassium (<jats:italic>p<\/jats:italic>\u2009=\u20090.04 day 1; <jats:italic>p<\/jats:italic>\u2009=\u20090.02 day 21) and median LDH values (<jats:italic>p<\/jats:italic>\u2009=\u20090.02 day 1, <jats:italic>p<\/jats:italic>\u2009=\u20090.05 day 21) were observed in PRBCs from male donors. A statistically significant positive association was observed between donor UA and LDH levels of PRBCs on day 35 of storage (<jats:italic>\u03b2<\/jats:italic> coefficient: 715.52, <jats:italic>p<\/jats:italic>\u2010value: 0.003) on multiple regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In vitro haemolysis of PRBCs is affected by blood donor characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13507","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T05:24:48Z","timestamp":1691040288000},"page":"835-842","source":"Crossref","is-referenced-by-count":3,"title":["Association of blood donor characteristics and in vitro haemolysis of packed red blood cell concentrates during storage"],"prefix":"10.1111","volume":"118","author":[{"given":"Bhuvandeep","family":"Dhawan","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6978-9140","authenticated-orcid":false,"given":"Kshitija","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-9064","authenticated-orcid":false,"given":"Paramjit","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Jaswal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Tahlan","sequence":"additional","affiliation":[{"name":"Department of Pathology Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0086-2132","authenticated-orcid":false,"given":"Ravneet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanvi","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Rohilla","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"27","article-title":"Red blood cell storage lesion: causes and potential clinical consequences","volume":"17","author":"Yoshida T","year":"2019","journal-title":"Blood Transfus"},{"key":"e_1_2_9_3_1","first-page":"s39","article-title":"Aging and death signaling in mature red cells: from basic science to transfusion practice","volume":"8","author":"Antonelou MH","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12378"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13745"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.201500128"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017004820"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16203"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14998"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2007.10719599"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559827616682933"},{"key":"e_1_2_9_12_1","first-page":"351","article-title":"Correlation between oxidative stress and antioxidant defence in south Indian urban vegetarians and non\u2010vegetarians","volume":"16","author":"Somannavar MS","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16168"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13211"},{"key":"e_1_2_9_15_1","unstructured":"Central Drugs Standard Control Organization.Drugs and Cosmetics Act 1940 and Amendments [Online] March2020[cited 2022 Nov 1]. Available from:https:\/\/cdsco.gov.in\/opencms\/opencms\/system\/modules\/CDSCO.WEB\/elements\/download_file_division.jsp?num_id=NTc2MQ==."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/23.4.749"},{"key":"e_1_2_9_17_1","unstructured":"Centers for Disease Control and Prevention.Body mass index (BMI) [Online]. [cited 2022 Nov 11]. Available fromhttps:\/\/www.cdc.gov\/healthyweight\/assessing\/bmi\/index.html."},{"key":"e_1_2_9_18_1","volume-title":"Global database: blood safety and availability [Internet]","author":"World Health Organisation (WHO)","year":"2020"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(98)00055-2"},{"key":"e_1_2_9_20_1","first-page":"291","article-title":"Blood rheology and aging","volume":"10","author":"Simmonds MJ","year":"2013","journal-title":"J Geriatr Cardiol"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01439.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4103\/ajts.ajts_61_21","article-title":"A study to assess the relationship between donor uric acid levels and supernatant hemolysis in stored packed red blood cell units","volume":"16","author":"Singh HK","year":"2022","journal-title":"Asian J Transfus Sci"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:21:01Z","timestamp":1697293261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/vox.13507"],"URL":"https:\/\/doi.org\/10.1111\/vox.13507","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]}}}