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Others are specifically related to the apheresis procedure, such as citrate reactions, haemolysis, infiltration and air embolism. Whilst plasmapheresis procedures are generally well tolerated, theoretical longer term donor health considerations, such as the effects on donor plasma protein levels, bone mineral density, iron deficiency and malignancy also require consideration. An evidence\u2010based framework that supports a safe and sustainable increase in the collection of plasma is essential. Our review demonstrates a lack of high\u2010quality evidence on risks and outcomes specifically in plasmapheresis. Whilst conservative procedural controls and donor harm minimization policies will mitigate risk, high\u2010quality evidence is needed to facilitate practice change that is safe and sustainable and maximizes the potential of individual donor differences.<\/jats:p>","DOI":"10.1111\/vox.13512","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T07:08:35Z","timestamp":1693292915000},"page":"94-101","source":"Crossref","is-referenced-by-count":14,"title":["A donor safety evidence literature review of the short\u2010 and long\u2010term effects of plasmapheresis"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-3661","authenticated-orcid":false,"given":"Veronica C.","family":"Hoad","sequence":"first","affiliation":[{"name":"Donor and Product Safety (DAPS) Policy Unit Australian Red Cross Lifeblood  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Castr\u00e9n","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Vantaa Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3718-4881","authenticated-orcid":false,"given":"Rut","family":"Norda","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Transfusion Medicine Uppsala University Hospital  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Pink","sequence":"additional","affiliation":[{"name":"Donor and Product Safety (DAPS) Policy Unit Australian Red Cross Lifeblood  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16078"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12977"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.03.014"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16333"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41040571.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12488"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408368209107032"},{"key":"e_1_2_10_9_1","volume-title":"The guide to the preparation, use and quality assurance of blood components","author":"European Directorate for the Quality of Medicines & HealthCare","year":"2020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16612"},{"key":"e_1_2_10_11_1","first-page":"224","article-title":"Prediction of blood volume in normal human adults","volume":"51","author":"Nadler SB","year":"1962","journal-title":"Surgery"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12387"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-018-0127-9"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25817"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217694099"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00934.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17169"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/03000605221121958"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13897"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17173"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20107"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21403"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21438"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.11.008"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2018.100188"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13907"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.04.001"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00033"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1975.15576082222.x"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1991.tb00879.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.1993.tb00105.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1999.77201072.x"},{"key":"e_1_2_10_33_1","unstructured":"JanssonU.Collection of plasma considering the calculated blood volume of the individual donor. 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