{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:32:05Z","timestamp":1758126725828,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Ferritin is commonly measured to evaluate iron stores in the body. Some countries have added or considered adding ferritin lower bounds to donor eligibility criteria. Ferritin is also elevated by inflammation. The main goal of this study is to estimate how different ferritin cut\u2010offs would affect the proportion of donors with a C\u2010reactive protein (CRP) level over 3\u2009mg\/L, which is the decision limit of the highest chronic cardiovascular risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>To simulate recruitment of new blood donors, we selected participants from two Finnish general population cohorts, namely FINRISK 1997 (<jats:italic>n<\/jats:italic>\u2009=\u20095369) and Health 2000 (<jats:italic>n<\/jats:italic>\u2009=\u20093278), that would likely fulfil the selection criteria of blood donation. We then calculated the proportion of individuals with high\u2010sensitivity CRP values above 3\u2009mg\/L, over a range of ferritin values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that for several ferritin cut\u2010offs the proportion of potential donors with CRP\u2009&gt;\u20093\u2009mg\/L would rise by a statistically significant amount. The trend was significant and similar for all subgroups but weaker for non\u2010menstruating women as well as men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that screening a population of potential blood donors with ferritin cut\u2010offs raises the number of people with CRP\u2009&gt;\u20093\u2009mg\/L within the blood donor population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13515","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T09:59:38Z","timestamp":1692957578000},"page":"901-905","source":"Crossref","is-referenced-by-count":1,"title":["Simulated effects of ferritin screening on C\u2010reactive protein levels in recruited blood donors"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8844-9344","authenticated-orcid":false,"given":"Esa","family":"Turkulainen","sequence":"first","affiliation":[{"name":"Research and Development Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3331-0307","authenticated-orcid":false,"given":"Jarkko","family":"Ihalainen","sequence":"additional","affiliation":[{"name":"Research and Development Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-8488","authenticated-orcid":false,"given":"Mikko","family":"Arvas","sequence":"additional","affiliation":[{"name":"Research and Development Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8040589"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15166"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196576"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220862"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13085"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa211"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12856"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088196"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214468"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214064"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:21:10Z","timestamp":1697293270000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/vox.13515"],"URL":"https:\/\/doi.org\/10.1111\/vox.13515","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"type":"print","value":"0042-9007"},{"type":"electronic","value":"1423-0410"}],"subject":[],"published":{"date-parts":[[2023,8,25]]}}}