{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:06:13Z","timestamp":1792037173978,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Repeated blood donation is a well\u2010known cause of iron deficiency among donors. However, present scientific literature lacks comprehensive evidence regarding the impact of regular plateletpheresis procedures on body iron reserves. In this study, we aimed to detect and correlate iron deficiency (using iron indices) with the frequency of platelet donations. Additionally, we also analysed the correlation between other iron and haematological indices with serum ferritin to determine cost\u2010effective parameters that may serve as an initial screening approach to determine which donors should be subjected to serum ferritin testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 180 male participants from our platelet donor registry were enrolled in this observational cross\u2010sectional study. Enrolment questionnaires were administered to eligible donors, and biological samples were collected during plateletpheresis donation. Biological tests such as complete blood count, reticulocyte indices, iron indices, vitamin B12 and folate were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Donors with \u226512 donations per year showed the highest prevalence of low ferritin (serum ferritin: 15\u201330\u2009ng\/mL) and absent iron stores (serum ferritin &lt;15\u2009ng\/mL) (41.3% and 26.7%, respectively). Ferritin showed a significant negative correlation with recent (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.346) and lifetime donations (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.196). The efficacy of other indices for identifying iron depletion was much better using a serum ferritin value &lt;15\u2009ng\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regular plateletpheresis donations can lead to varying severities of non\u2010anaemic iron deficiency. Blood centres must regularly monitor frequent plateletpheresis donors (especially donors with more than 11 donations in a calendar year) and ideally maintain their serum ferritin above 30\u2009ng\/mL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13525","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:04:37Z","timestamp":1695985477000},"page":"921-929","source":"Crossref","is-referenced-by-count":5,"title":["\u2018Ironing out the risk\u2019: Assessing the effect of plateletpheresis donation frequency on iron stores in South\u2010Asian male donors"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8774-7599","authenticated-orcid":false,"given":"Deep","family":"Madkaiker","sequence":"first","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Kasturba Medical College, Manipal, Manipal Academy of Higher Education  Manipal Karnataka India"},{"name":"Department of Transfusion Medicine Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumathi S.","family":"Hiregoudar","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Chavan","sequence":"additional","affiliation":[{"name":"Composite Laboratory Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Kasturba Medical College, Manipal, Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-2326","authenticated-orcid":false,"given":"Shamee","family":"Shastry","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Kasturba Medical College, Manipal, Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12991"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.229450"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2016.06.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.10.002"},{"key":"e_1_2_9_6_1","unstructured":"AABB Donor Iron Deficiency Risk\u2010Based Decision\u2010Making Assessment Report\u2010Supplemental Material. Available from:https:\/\/www.aabb.org\/docs\/default\u2010source\/default\u2010document\u2010library\/resources\/aabb\u2010donor\u2010iron\u2010deficiency\u2010rbdm\u2010assessment\u2010report\u2010supplemental\u2010material.pdf?sfvrsn=1fa7fc3_0. Last accessed 30 May 2023."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119719809.ch7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.11.002"},{"key":"e_1_2_9_9_1","volume-title":"National Family Health Survey (NFHS\u20105), 2019\u201021: India: Volume I","author":"International Institute for Population Sciences (IIPS) and ICF","year":"2021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-5710(95)00426-2"},{"key":"e_1_2_9_11_1","volume-title":"Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. 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