{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:46Z","timestamp":1747188466870,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:00:00Z","timestamp":1696550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The <jats:italic>FUT2<\/jats:italic> gene is responsible for the synthesis of the H antigen in body secretions. It is highly polymorphic and population specific. We investigated the <jats:italic>FUT2<\/jats:italic> gene polymorphism in Chinese blood donors and found a novel deletion mutation in one non\u2010secretor individual. This study aimed to identify mutation(s) responsible for a non\u2010secretor phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The Lewis blood group of a Chinese Han blood donor was typed using the standard serological technique and the <jats:italic>FUT2<\/jats:italic> gene of the sample was analysed by Sanger sequencing. Clone sequencing was performed for determining the haplotype of the <jats:italic>FUT2<\/jats:italic> gene. Bioinformatics tools were used for predicting the effect of the deletion on the <jats:italic>FUT2<\/jats:italic> gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A novel nine\u2010base deletion (c.461_469delGGACCTTCT) in the <jats:italic>FUT2<\/jats:italic> gene was identified in a Chinese Han blood donor. Two haplotypes Se<jats:sup>390,418<\/jats:sup> and se<jats:sup>204,249,461_469del,772,993<\/jats:sup> were determined by clone sequencing. According to the prediction of bioinformatics tools, the mutation at c.461_469delGGACCTTCT might not influence the activity of the Se enzyme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We identified a new <jats:italic>FUT2<\/jats:italic> mutation, the deletion of nine bases (c.461_469delGGACCTTCT), in a Chinese Han blood donor. This deletion was reported for the first time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13528","type":"journal-article","created":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:58:57Z","timestamp":1696582737000},"page":"988-992","source":"Crossref","is-referenced-by-count":0,"title":["A novel allele of <scp><i>FUT2<\/i><\/scp> gene containing a deletion of nine bases (c.461_469delGGACCTTCT) in a Chinese Han blood donor"],"prefix":"10.1111","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9295-7747","authenticated-orcid":false,"given":"Shihang","family":"Zhou","sequence":"first","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Laboratory Medicine Dalian Medical University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Song","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Xia","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-4957","authenticated-orcid":false,"given":"Linnan","family":"Shao","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohua","family":"Liang","sequence":"additional","affiliation":[{"name":"Dalian Blood Center  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1989.tb03040.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.9.4640"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msp108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02293.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01280.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050599"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13050931"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15298"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-006-0203-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040803"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719-009-9255-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2021.04.004"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T21:31:11Z","timestamp":1700083871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,6]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1111\/vox.13528"],"URL":"https:\/\/doi.org\/10.1111\/vox.13528","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"type":"print","value":"0042-9007"},{"type":"electronic","value":"1423-0410"}],"subject":[],"published":{"date-parts":[[2023,10,6]]}}}