{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:14:35Z","timestamp":1789038875913,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>As part of a large\u2010scale project to safely increase plasma collection in Europe, the current scoping review identifies the existing evidence (gaps) on adverse events (AEs) and other health effects in plasmapheresis donors, as well as factors that may be associated with such events\/effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We searched six databases and three registries. Study characteristics (publication type, language, study design, population, outcomes, associated factors, time of assessment, duration of follow\u2010up, number and frequency of donations, convalescent plasma [y\/n], setting and location) were synthesized narratively and in an interactive evidence gap map (EGM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ninety\u2010four research articles and five registrations were identified. Around 90% were observational studies (57 controlled and 33 uncontrolled), and most of them were performed in Europe (55%) or the United States (20%). Factors studied in association with donor health included donor characteristics (e.g., sex, age) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200927), cumulative number of donations (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), donation frequency (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911), plasma collection device or programme (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911), donor status (first time vs. repeat) (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910), donation volume per session (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), time in donation programme (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093), preventive measures (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092) or other (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current scoping review provides an accessible tool for researchers and policymakers to identify the available evidence (gaps) concerning plasmapheresis donation safety. Controlled prospective studies with long\u2010term donor follow\u2010up are scarce. Furthermore, additional experimental studies comparing the health effects of different donation frequencies are required to inform a safe upper limit for donation frequency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.13544","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:33:14Z","timestamp":1697067194000},"page":"110-120","source":"Crossref","is-referenced-by-count":13,"title":["Safety and protection of plasma donors: A scoping review and evidence gap map"],"prefix":"10.1111","volume":"119","author":[{"given":"Natalie","family":"Schroyens","sequence":"first","affiliation":[{"name":"Centre for Evidence\u2010Based Practice, Belgian Red Cross Mechelen Belgium"},{"name":"Department of Public Health and Primary Care KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-780X","authenticated-orcid":false,"given":"Tine","family":"D'aes","sequence":"additional","affiliation":[{"name":"Centre for Evidence\u2010Based Practice, Belgian Red Cross Mechelen Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4498-9781","authenticated-orcid":false,"given":"Emmy","family":"De Buck","sequence":"additional","affiliation":[{"name":"Centre for Evidence\u2010Based Practice, Belgian Red Cross Mechelen Belgium"},{"name":"Department of Public Health and Primary Care KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-8322","authenticated-orcid":false,"given":"Pierre","family":"Tiberghien","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang Saint\u2010Denis France"},{"name":"Universit\u00e9 de Franche\u2010Comt\u00e9, EFS, INSERM, UMR Right Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-6003","authenticated-orcid":false,"given":"Katja","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Donor Medicine Research \u2013 Donor Studies, Sanquin Research Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health, Amsterdam Public Health research institute Amsterdam UMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerle","family":"Compernolle","sequence":"additional","affiliation":[{"name":"Belgian Red Cross, Blood Services Mechelen Belgium"},{"name":"Faculty of Medicine and Health Sciences University of Ghent Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-1799","authenticated-orcid":false,"given":"Hans","family":"Van Remoortel","sequence":"additional","affiliation":[{"name":"Centre for Evidence\u2010Based Practice, Belgian Red Cross Mechelen Belgium"},{"name":"Department of Public Health and Primary Care KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16078"},{"key":"e_1_2_9_3_1","unstructured":"European Blood Alliance Strengthening Plasma Collection in Europe. 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