{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:51Z","timestamp":1747188471331,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC\u201018\u201003"],"award-info":[{"award-number":["PPOC\u201018\u201003"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Donor characteristics have been implicated in transfusion\u2010related adverse events. Uncertainty remains about whether sex, and specifically pregnancy history of the blood donor, could affect patient outcomes. Whether storage duration of the blood product could be important for patient outcomes has also been investigated, and a small detrimental effect of fresh products remains a possibility. Here, we hypothesize that fresh red blood cell products donated by ever\u2010pregnant donors are associated with mortality in male patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We used data from a cohort study of adult patients receiving a first transfusion between 2005 and 2015 in the Netherlands. The risk of death after receiving a transfusion from one of five exposure categories (female never\u2010pregnant stored \u226410\u2009days, female never\u2010pregnant stored &gt;10\u2009days, female ever\u2010pregnant stored \u226410\u2009days, female ever\u2010pregnant stored &gt;10\u2009days and male stored for \u226410\u2009days), compared to receiving a unit donated by a male donor, which was stored for &gt;10\u2009days (reference), was calculated using a Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 42,456 patients who contributed 88,538 person\u2010years in total, of whom 13,948 died during the follow\u2010up of the study (33%). Fresh units (stored for \u226410\u2009days) from ever\u2010pregnant donors were associated with mortality in male patients, but the association was not statistically significant (hazard ratio 1.39, 95% confidence interval 0.97\u20131.99). Sensitivity analyses did not corroborate this finding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings do not consistently support the notion that the observed association between ever\u2010pregnant donor units and mortality is mediated by blood product storage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13551","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T07:39:28Z","timestamp":1698997168000},"page":"43-52","source":"Crossref","is-referenced-by-count":2,"title":["Donor pregnancies and transfusion recipient mortality: A role for red blood cell storage?"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3964-2505","authenticated-orcid":false,"given":"Sarah J.","family":"Valk","sequence":"first","affiliation":[{"name":"Jon J van Rood Center for Clinical Transfusion Research Sanquin\/LUMC  Leiden The Netherlands"},{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3161-5684","authenticated-orcid":false,"given":"Camila","family":"Caram\u2010Deelder","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothea","family":"Evers","sequence":"additional","affiliation":[{"name":"Department of Haematology Radboudumc  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen M. K.","family":"de Vooght","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daan","family":"van de Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Haematology Catharina Hospital  Eindhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle J.","family":"Wondergem","sequence":"additional","affiliation":[{"name":"Department of Haematology Amsterdam UMC, Location VUmc  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie C. V.","family":"P\u00e9qu\u00e9riaux","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Haematology Jeroen Bosch Hospital  's\u2010Hertogenbosch The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5298-7212","authenticated-orcid":false,"given":"Francisca","family":"Hudig","sequence":"additional","affiliation":[{"name":"LabWest, Haga Teaching Hospital  The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap Jan","family":"Zwaginga","sequence":"additional","affiliation":[{"name":"Jon J van Rood Center for Clinical Transfusion Research Sanquin\/LUMC  Leiden The Netherlands"},{"name":"Department of Haematology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"de Korte","sequence":"additional","affiliation":[{"name":"Department of Product and Process Development, Sanquin Blood Bank  Amsterdam The Netherlands"},{"name":"Department of Blood Cell Research, Sanquin Research, and Landsteiner Laboratory University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo M. G.","family":"van de Watering","sequence":"additional","affiliation":[{"name":"Jon J van Rood Center for Clinical Transfusion Research Sanquin\/LUMC  Leiden The Netherlands"},{"name":"Department of Transfusion Medicine Sanquin Blood Bank  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rutger A.","family":"Middelburg","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Public Health and Primary Care Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna G.","family":"van der Bom","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1309\/AJCP6SBPOX0UWHEK"},{"key":"e_1_2_9_3_1","first-page":"351","article-title":"Implementation and outcomes of a transfusion\u2010related acute lung injury surveillance programme and study of HLA\/HNA alloimmunisation in blood donors","volume":"10","author":"Porretti L","year":"2012","journal-title":"Blood Transfus"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1111\/j.1398-9995.2005.00870.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1111\/j.1423-0410.2011.01487.x"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1001\/jama.2017.14825"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1136\/bmj.319.7223.1492"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1001\/jama.2019.7084"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.2105\/AJPH.2018.304337"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1016\/j.tmrv.2018.02.002"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1016\/j.tmrv.2012.06.002"},{"unstructured":"ValkSJ Caram\u2010DeelderC EversD De VooghtKMK Van de KerkhofD WondergemMJ et al.Donor pregnancies and transfusion recipient mortality: a role for red blood cell storage?2019Conference: 29th Regional Congress of the ISBT Basel.","key":"e_1_2_9_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1016\/S2352-3026(16)30019-9"},{"key":"e_1_2_9_14_1","article-title":"Risk factors for alloimmunisation after red blood cell transfusions (R\u2010FACT): a case cohort study","volume":"2","author":"Zalpuri S","year":"2012","journal-title":"BMJ"},{"volume-title":"Stata statistical software: release 16","year":"2019","author":"StataCorp","key":"e_1_2_9_15_1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_16_1","DOI":"10.1093\/aje\/kwk052"},{"unstructured":"CBO.Dutch Guideline Bloodtransfusion. 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