{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:18:50Z","timestamp":1784269130329,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Although the genetic determinants of haemoglobin and ferritin have been widely studied, those of the clinically and globally relevant iron deficiency anaemia (IDA) and deferral due to hypohaemoglobinemia (Hb\u2010deferral) are unclear. In this investigation, we aimed to quantify the value of genetic information in predicting IDA and Hb\u2010deferral.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We analysed genetic data from up to 665,460 participants of the FinnGen, Blood Service Biobank and UK Biobank, and used INTERVAL (<jats:italic>N<\/jats:italic>\u2009=\u200939,979) for validation.<\/jats:p><jats:p>We performed genome\u2010wide association studies (GWASs) of IDA and Hb\u2010deferral and utilized publicly available genetic associations to compute polygenic scores for IDA, ferritin and Hb. We fitted models to estimate the effect sizes of these polygenic risk scores (PRSs) on IDA and Hb\u2010deferral risk while accounting for the individual's age, sex, weight, height, smoking status and blood donation history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant variants in GWASs of IDA and Hb\u2010deferral appear to be a small subset of variants associated with ferritin and Hb. Effect sizes of genetic predictors of IDA and Hb\u2010deferral are similar to those of age and weight which are typically used in blood donor management. A total genetic score for Hb\u2010deferral was estimated for each individual. The odds ratio estimate between first decile against that at ninth decile of total genetic score distribution ranged from 1.4 to 2.2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The value of genetic data in predicting IDA or suitability to donate blood appears to be on a practically useful level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13564","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T08:00:14Z","timestamp":1701244814000},"page":"34-42","source":"Crossref","is-referenced-by-count":9,"title":["The value of genetic data from 665,460 individuals in managing iron deficiency anaemia and suitability to donate blood"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-5831","authenticated-orcid":false,"given":"Jarkko","family":"Toivonen","sequence":"first","affiliation":[{"name":"Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Allara","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care University of Cambridge  Cambridge UK"},{"name":"Heart and Lung Research Institute University of Cambridge  Cambridge UK"},{"name":"National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"FinnGen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Castr\u00e9n","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"di Angelantonio","sequence":"additional","affiliation":[{"name":"British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care University of Cambridge  Cambridge UK"},{"name":"Heart and Lung Research Institute University of Cambridge  Cambridge UK"},{"name":"National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour University of Cambridge  Cambridge UK"},{"name":"British Heart Foundation Centre of Research Excellence University of Cambridge  Cambridge UK"},{"name":"Health Data Research UK Cambridge Wellcome Genome Campus and University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-8488","authenticated-orcid":false,"given":"Mikko","family":"Arvas","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.Anaemia Policy Brief.2012. Available from:http:\/\/www.who.int\/\/iris\/bitstream\/10665\/148556\/1\/WHO_NMH_NHD_14.4_eng.pdf. Last accessed 24 Jan 2023."},{"key":"e_1_2_9_3_1","unstructured":"WHO.Prevalence of anaemia in women of reproductive age. The Global Health Observatory.2021. Available from:https:\/\/www.who.int\/data\/gho\/data\/indicators\/indicator\u2010details\/GHO\/prevalence\u2010of\u2010anaemia\u2010in\u2010women\u2010of\u2010reproductive\u2010age. Last accessed 24 Jan 2023."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.195552"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32594-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15136"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01292.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15676"},{"key":"e_1_2_9_9_1","first-page":"25","article-title":"Commission Directive 2004\/33\/EC implementing Directive 2002\/98\/EC of the European Parliament and of the council as regards certain technical requirements for blood and blood components","volume":"91","year":"2004","journal-title":"Off J Eur Union"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0579-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09718-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00829-7"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.119.302077"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.045"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.04.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-01575-z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2019.01.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00114"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04103-z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21952-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0184-y"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31928-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15743"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa840"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0974-4"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13066"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5926"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.10.042"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1322563111"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13564","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T11:46:45Z","timestamp":1705837605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13564"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/vox.13564"],"URL":"https:\/\/doi.org\/10.1111\/vox.13564","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]}}}