{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:22:58Z","timestamp":1792070578070,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","award":["PPOC20\u201005\/2490"],"award-info":[{"award-number":["PPOC20\u201005\/2490"]}],"id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["BRC\u20101215\u201020014"],"award-info":[{"award-number":["BRC\u20101215\u201020014"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Red blood cell (RBC) transfusions pose a risk of alloantibody development in patients. For patients with increased alloimmunization risk, extended preventive matching is advised, encompassing not only the ABO\u2010D blood groups but also the most clinically relevant minor antigens: C, c, E, e, K, Fy<jats:sup>a<\/jats:sup>, Fy<jats:sup>b<\/jats:sup>, Jk<jats:sup>a<\/jats:sup>, Jk<jats:sup>b<\/jats:sup>, S and s. This study incorporates patient\u2010specific data and the clinical consequences of mismatching into the allocation process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We have redefined the MINimize Relative Alloimmunization Risks (MINRAR) model to include patient group preferences in selecting RBC units from a finite supply. A linear optimization approach was employed, considering both antigen immunogenicity and the clinical impact of mismatches for specific patient groups. We also explore the advantages of informing the blood bank about scheduled transfusions, allowing for a more strategic blood distribution. The model is evaluated using historical data from two Dutch hospitals, measuring shortages and minor antigen mismatches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The updated model, emphasizing patient group\u2010specific considerations, achieves a similar number of mismatches as the original, yet shifts mismatches among patient groups and antigens, reducing expected alloimmunization consequences. Simultaneous matching for multiple hospitals at the distribution centre level, considering scheduled demands, led to a 30% decrease in mismatches and a 92% reduction in shortages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reduction of expected alloimmunization consequences by incorporating patient group preferences demonstrates our strategy's effectiveness for patient health. Substantial reductions in mismatches and shortages with multi\u2010hospital collaboration highlights the importance of sharing information in the blood supply chain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13594","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T03:48:52Z","timestamp":1706586532000},"page":"368-376","source":"Crossref","is-referenced-by-count":12,"title":["Extensive red blood cell matching considering patient alloimmunization risk"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-3392","authenticated-orcid":false,"given":"Merel L.","family":"Wemelsfelder","sequence":"first","affiliation":[{"name":"Donor Medicine Research Department Sanquin Research  Amsterdam the Netherlands"},{"name":"Business Analytics Department University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0577-1712","authenticated-orcid":false,"given":"Ronald H. G.","family":"van de Weem","sequence":"additional","affiliation":[{"name":"Donor Medicine Research Department Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-6794","authenticated-orcid":false,"given":"Jessie S.","family":"Luken","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam the Netherlands"},{"name":"Department of Experimental Immunohematology Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-0525","authenticated-orcid":false,"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam the Netherlands"},{"name":"Department of Experimental Immunohematology Sanquin Research  Amsterdam the Netherlands"},{"name":"Department of Hematology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9 W. L. M.","family":"Niessen","sequence":"additional","affiliation":[{"name":"OLVG Laboratory BV  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8065-3540","authenticated-orcid":false,"given":"C. 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