{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:23:07Z","timestamp":1790770987508,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["2020.0234"],"award-info":[{"award-number":["2020.0234"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019\u201001683"],"award-info":[{"award-number":["2019\u201001683"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>\n                      Polymorphic molecules expressed on the surface of certain blood cells are traditionally categorized as blood groups and human platelet or neutrophil antigens. CD36 is widely considered a platelet antigen (Nak\n                      <jats:sup>a<\/jats:sup>\n                      ) and anti\u2010CD36 can cause foetal\/neonatal alloimmune thrombocytopenia (FNAIT) in CD36\u2010negative pregnant women. CD36 is used as a marker of differentiation in early erythroid culture. During the experimental culture of CD34+ cells from random blood donors, we observed that one individual lacked CD36. We sought to investigate this observation further and determine if CD36 fulfils the International Society of Blood Transfusion criteria for becoming a blood group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Surface markers were monitored by flow cytometry on developing cells during the erythroid culture of CD34+ cells. Genetic and flow cytometric analyses on peripheral blood cells were performed. Proteomic datasets were analysed, and clinical case reports involving anti\u2010CD36 and foetal anaemia were scrutinized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sequencing of\n                      <jats:italic>CD36\u2010<\/jats:italic>\n                      cDNA identified homozygosity for c.1133G&gt;T\/p.Gly378Val in the CD36\u2010negative donor. The minor allele frequency of rs146027667:T is 0.1% globally and results in abolished CD36 expression. CD36 has been considered absent from mature red blood cells (RBCs); however, we detected CD36 expression on RBCs and reticulocytes from 20 blood donors. By mining reticulocyte and RBC datasets, we found evidence for CD36\u2010derived peptides enriched in the membrane fractions. Finally, our literature review revealed severe cases of foetal anaemia attributed to anti\u2010CD36.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on these findings, we conclude that CD36 fulfils the criteria for becoming a new blood group system and that anti\u2010CD36 is implicated not only in FNAIT but also foetal anaemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.13595","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T21:58:43Z","timestamp":1707343123000},"page":"496-504","source":"Crossref","is-referenced-by-count":20,"title":["Evidence that\n                    <scp>CD36<\/scp>\n                    is expressed on red blood cells and constitutes a novel blood group system of clinical importance"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-4416","authenticated-orcid":false,"given":"Abdul Ghani","family":"Alattar","sequence":"first","affiliation":[{"name":"Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"},{"name":"Lund Stem Cell Center Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2940-2604","authenticated-orcid":false,"given":"Jill R.","family":"Storry","sequence":"additional","affiliation":[{"name":"Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"},{"name":"Lund Stem Cell Center Lund University  Lund Sweden"},{"name":"Department of Clinical Immunology and Transfusion Medicine Office for Medical Services  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-9610","authenticated-orcid":false,"given":"Martin L.","family":"Olsson","sequence":"additional","affiliation":[{"name":"Division of Hematology and Transfusion Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"},{"name":"Lund Stem Cell Center Lund University  Lund Sweden"},{"name":"Department of Clinical Immunology and Transfusion Medicine Office for Medical Services  Lund 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