{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T05:32:17Z","timestamp":1781069537780,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Malaria continues to be a significant public health concern in India, with several regions experiencing endemicity and sporadic outbreaks. The prevalence of malaria in blood donors, in India, varies between 0.02% and 0.07%. Common techniques to screen for malaria, in blood donors and patients, include microscopic smear examination and rapid diagnostic tests (RDTs) based on antigen detection. The aim of this study was to evaluate a new fully automated analyser, XN\u201031, for malaria detection, as compared with current practice of using RDT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Cross\u2010sectional analytical study was conducted to evaluate clinical sensitivity and specificity of new automated analyser XN\u201031 among blood donors' samples and clinical samples (patients with suspicion of malaria) from outpatient clinic collected over between July 2021 and October 2022. No additional sample was drawn from blood donor or patient. All blood donors and patients' samples were processed by malaria rapid diagnostic test, thick\u2010smear microscopy (MIC) and the haematology analyser XN\u201031. Any donor blood unit incriminated for malaria was discarded. Laboratory diagnosis using MIC was considered the \u2018gold standard\u2019 in the present study. Clinical sensitivity and specificity of XN\u201031 were compared with the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fife thousand and five donor samples and 82 diagnostic samples were evaluated. While the clinical sensitivity and specificity for donor samples were 100%, they were 72.7% and 100% for diagnostic samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Automated haematology analysers represent a promising solution, as they can deliver speedy and sensitive donor malaria screening assessments. This method also has the potential to be used for pre\u2010transfusion malaria screening along with haemoglobin estimation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13621","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T05:54:00Z","timestamp":1711346040000},"page":"556-562","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of new haematology analyser, <scp>XN<\/scp>\u201031, for malaria detection in blood donors: A single\u2010centre study from India"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-3877","authenticated-orcid":false,"given":"Aseem Kumar","family":"Tiwari","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Medanta\u2010The Medicity, Sector\u201038  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medanta\u2010The Medicity, Sector\u201038  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Medanta\u2010The Medicity, Sector\u201038  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan Kumar","family":"Gahlot","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medanta\u2010The Medicity, Sector\u201038  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medanta\u2010The Medicity, Sector\u201038  Gurgaon India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8134-7051","authenticated-orcid":false,"given":"Vaibhav","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Sysmex India Pvt. 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