{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:33:38Z","timestamp":1791416018533,"version":"4.3.3"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CTP 87518"],"award-info":[{"award-number":["CTP 87518"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001547","name":"China Medical Board","doi-asserted-by":"publisher","award":["14\u2010194"],"award-info":[{"award-number":["14\u2010194"]}],"id":[{"id":"10.13039\/100001547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>National\u2010level data on the incidence of red blood cell (RBC) transfusions and outcomes among very preterm infants (VPIs) are lacking in China. This study aims to describe the use and variation of RBC transfusion among VPIs in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This cohort study was conducted among 70 tertiary hospitals participating in the Chinese Neonatal Network (CHNN) from 2019 to 2020 across China. All VPIs admitted to the CHNN neonatal intensive care units (NICUs) were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 13,447 VPIs were enrolled, of whom 7026 (52.2%) received \u22651 RBC transfusions. The mean number of transfusions per infant was 2 (interquartile range [IQR] 1\u20134 times) and the median age at first transfusion was 15\u2009days (IQR 3\u201327\u2009days). The transfusion rate was higher in critically ill infants compared with non\u2010critically ill infants (70.5% vs. 39.3%). The transfusion rate varied widely (13.5%\u201395.0%) between different NICUs. The prevalence of death, severe intra\u2010ventricular haemorrhage, necrotizing enterocolitis (NEC) or spontaneous intestinal perforation (SIP), sepsis, bronchopulmonary dysplasia (BPD), severe retinopathy of prematurity (ROP) and cystic periventricular leukomalacia (cPVL) was significantly higher in the transfused group. Among non\u2010critically ill infants, RBC transfusion was independently associated with BPD, severe ROP and cPVL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study, providing the first baseline data on RBC transfusions among VPIs in China, shows an alarmingly high RBC transfusion rate with significant site variations. There is an urgent need for national guidelines on RBC transfusions for VPIs in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.13622","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T02:04:27Z","timestamp":1713233067000},"page":"572-580","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics of red blood cell transfusion among very preterm infants in China"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2035-6908","authenticated-orcid":false,"given":"Lu","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Gu","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Neonatal Diseases Fudan University, Children's Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongling","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Shaanxi Provincial People's Hospital  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University  Shanghai China"},{"name":"NHC Key Laboratory of Neonatal Diseases Fudan University, Children's Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University  Shanghai China"},{"name":"NHC Key Laboratory of Neonatal Diseases Fudan University, Children's Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoo K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mount Sinai Hospital and University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University  Shanghai China"},{"name":"NHC Key Laboratory of Neonatal Diseases Fudan University, Children's Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-2159","authenticated-orcid":false,"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neonatology Children's Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.18904"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2015.12.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.9-11-e520"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0247-6"},{"key":"e_1_2_9_6_1","first-page":"40","article-title":"Red blood cell transfusions in preterm newborns and neurodevelopmental outcomes at 2 and 5\u2009years of age","volume":"20","author":"Fontana C","year":"2022","journal-title":"Blood Transfus"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12998"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12234"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03081.x"},{"key":"e_1_2_9_10_1","first-page":"113","article-title":"Red blood cell transfusions and potentially related morbidities in neonates under 32\u2009weeks' gestation","volume":"19","author":"D'Amato G","year":"2021","journal-title":"Blood Transfus"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.157"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-2872"},{"key":"e_1_2_9_13_1","first-page":"88","article-title":"Effects of red blood cell transfusions on the risk of developing complications or death: an observational study of a cohort of very low birth weight infants","volume":"34","author":"Ghirardello S","year":"2017","journal-title":"Am J Perinat"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.814194"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15216"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.9185"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2020248"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10690"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80282-0"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80734-9"},{"key":"e_1_2_9_27_1","first-page":"97","article-title":"Chinese neonatal birth weight curve for different gestational age","volume":"53","author":"Zhu L","year":"2015","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00997.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.026"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.23580"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.04.002"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12998"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.10.231"},{"key":"e_1_2_9_34_1","first-page":"e1","article-title":"Red blood cell transfusions are independently associated with intra\u2010hospital mortality in very low birth weight preterm infants","volume":"159","author":"Santos AM","year":"2011","journal-title":"J Pediatr"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.84.3.F188"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T15:14:43Z","timestamp":1718118883000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/vox.13622"],"URL":"https:\/\/doi.org\/10.1111\/vox.13622","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]}}}