{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:06:58Z","timestamp":1788566818039,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003127","name":"Punainen Risti Veripalvelu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003127","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Blood donors are at risk of developing iron deficiency (ID) (ferritin &lt;15\u2009\u03bcg\/L, World Health Organization definition). Blood services implement different strategies to mitigate this risk. Although in Finland risk group\u2010based iron supplementation is in place, no iron supplementation is provided in the Netherlands. We aim to describe differences in ferritin levels and ID prevalence in donor and general populations in these countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Six cohorts, stratified based on sex, and for women age, in the Netherlands and Finland were used to evaluate differences in ferritin levels and ID between donor populations (Donor InSight\u2010III and FinDonor 10,000) and general populations (Prevention of Renal and Vascular End\u2010Stage Disease [PREVEND], FinRisk 1997 and Health 2000) and newly registered Dutch donors. Multivariable logistic regression was used to quantify associations of various explanatory factors with ID.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 13,443 Dutch and 13,933 Finnish subjects were included. Donors, except for women aged \u226450\u2009years old in Finland, had lower median ferritin levels compared with the general population and new donors. Dutch regular blood donors had higher or similar prevalence of ID as compared with the Dutch general population, including new donors. In contrast, Finnish donors showed similar prevalence of ID compared with the general population, except for a markedly lower prevalence in \u226450\u2010year\u2010old women who routinely receive iron supplements when donating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron status in blood donors differs from that in the general population. The Finnish blood service donor management policy, for example, iron supplementation for risk groups, seemingly protects young female blood donors from developing ID.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13639","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T06:04:10Z","timestamp":1713247450000},"page":"664-674","source":"Crossref","is-referenced-by-count":4,"title":["Iron status in Dutch and Finnish blood donor and general populations: A cross\u2010cohort comparison study"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-4929","authenticated-orcid":false,"given":"Jan H. M.","family":"Karregat","sequence":"first","affiliation":[{"name":"Donor Studies, Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Department of Public Health Amsterdam Public Health (APH) Research Institute, Academic Medical Center, Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2135-2545","authenticated-orcid":false,"given":"Sofie","family":"Ekroos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Castr\u00e9n","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service (FRCBS), Research and Development  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-8488","authenticated-orcid":false,"given":"Mikko","family":"Arvas","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service (FRCBS), Research and Development  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-6003","authenticated-orcid":false,"given":"Katja","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Donor Studies, Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Department of Public Health Amsterdam Public Health (APH) Research Institute, Academic Medical Center, Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16688"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15906"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-04-709451"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13195"},{"key":"e_1_2_9_6_1","unstructured":"Wet inzake bloedvoorziening.1997."},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(05)80052-5"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04648-w"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14984"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12431"},{"key":"e_1_2_9_11_1","first-page":"20","article-title":"International forum: an investigation of iron status in blood donors","volume":"15","author":"Vuk T","year":"2017","journal-title":"Blood Transfus"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12731"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000031732.78052.81"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12856"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyx239"},{"key":"e_1_2_9_16_1","unstructured":"HeistaroS.Methodology report: health 2000 survey. Helsinki: National Public Health Institute.2008."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v080.i01"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/rssa.12378"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15179"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13426"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01671.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220862"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25800"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24784"},{"key":"e_1_2_9_25_1","unstructured":"OECD.Fertility rates (indicator).2024.https:\/\/doi.org\/10.1787\/8272fb01-enLast accessed 2024 Jan 15."},{"key":"e_1_2_9_26_1","article-title":"Combined hormonal contraceptives for heavy menstrual bleeding","volume":"2","author":"Lethaby A","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab035"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15676"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-014-0625-1"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvac099"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13639","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T06:42:42Z","timestamp":1720593762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,15]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/vox.13639"],"URL":"https:\/\/doi.org\/10.1111\/vox.13639","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,15]]}}}