{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:05Z","timestamp":1747188485308,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016170","name":"Japan Blood Products Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>In May 2022, the United Kingdom reported the first case of chained transmission of the monkeypox (mpox) virus without any known epidemiological links to west or central Africa. The monthly number of mpox patients currently has passed a peak and is declining globally, and infected patients include both non\u2010vaccinated and vaccinated individuals. Herein, the virus\u2010neutralizing (VN) activity against vaccinia viruses, which are considered to cross\u2010react with the mpox virus, in the intravenous immunoglobulin (IVIG) lots derived from donors, including vaccinated Japanese populations, was evaluated to clarify the status of the Japanese blood donor population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>VN titres against vaccinia and human mpox viruses in IVIG lots derived from donors in Japan and the United States manufactured between 1999 and 2021 and 1995 and 2001, respectively, were evaluated by neutralization testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VN titres of IVIG derived from donors in Japan and the United States against vaccinia and mpox viruses showed a slowly decreasing trend between 1999 and 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VN titres are expected to decrease in the future since the percentage of vaccinated donors in the donor population seems to have decreased. Therefore, continuous monitoring of VN titres is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13655","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:44:11Z","timestamp":1715589851000},"page":"878-882","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010monkeypox virus\u2010neutralizing activities of human immunoglobulin manufactured between 1999 and 2021 and derived from donors in the United States and Japan"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-5894","authenticated-orcid":false,"given":"Mikihiro","family":"Yunoki","sequence":"first","affiliation":[{"name":"Research and Development Division Japan Blood Products Organization  Tokyo Japan"},{"name":"Department of Viral Infections Research Institute for Microbial Diseases, Osaka University  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritsuko","family":"Kubota\u2010Koketsu","sequence":"additional","affiliation":[{"name":"Department of Viral Infections Research Institute for Microbial Diseases, Osaka University  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Shioda","sequence":"additional","affiliation":[{"name":"Department of Viral Infections Research Institute for Microbial Diseases, Osaka University  Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.History of the smallpox vaccine.https:\/\/www.who.int\/news\u2010room\/spotlight\/history\u2010of\u2010vaccination\/history\u2010of\u2010smallpox\u2010vaccination?topicsurvey=ht7j2q)&gclid=EAIaIQobChMIhquputyAgQMV4M8WBR0pFw\u2010tEAAYASABEgLQifD_BwE. Last accessed 29 Aug 2023."},{"key":"e_1_2_9_3_1","first-page":"520","article-title":"Persisting humoral antiviral immunity within the Japanese population after the discontinuation in 1976 of routine smallpox vaccinations","volume":"12","author":"Hatakeyama S","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"e_1_2_9_4_1","first-page":"50","article-title":"Status of smallpox antibody retention 28\u2009years after the abolition of smallpox vaccine","volume":"52","author":"Takeuchi Y","year":"2006","journal-title":"Modern Media"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0042-9007.2004.00397.x"},{"key":"e_1_2_9_6_1","unstructured":"European Centre for Disease Prevention and Control.Monkeypox multi\u2010country outbreak.2022.https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/Monkeypox\u2010multi\u2010country\u2010outbreak.pdf. Last accessed 7 Jul 2023."},{"key":"e_1_2_9_7_1","unstructured":"WHO.Multi\u2010country outbreak of mpox.https:\/\/www.who.int\/publications\/m\/item\/multi\u2010country\u2010outbreak\u2010of\u2010mpox\u2010\u2010external\u2010situation\u2010report\u201029\u2010\u2010\u201020\u2010october\u20102023. Last accessed 29 Oct 2023."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207323"},{"key":"e_1_2_9_9_1","unstructured":"WHO.Vaccines and immunization for monkeypox: Interim guidance.2022.https:\/\/www.who.int\/publications\/i\/item\/WHO\u2010MPX\u2010Immunization. Last accessed 28 Jul 2023."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(90)90194-V"},{"key":"e_1_2_9_11_1","unstructured":"Japanese Government Statistics.Population estimates.https:\/\/www.e\u2010stat.go.jp\/en\/stat\u2010search\/files?page=1&layout=datalist&toukei=00200524&tstat=000000090001&cycle=7&tclass1=000001011679&tclass2val=0. 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Last accessed 31 Aug 2023."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(98)00125-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08429-z"},{"key":"e_1_2_9_15_1","first-page":"307","article-title":"The minimum protective level of antibodies in smallpox","volume":"52","author":"Sarkar JK","year":"1975","journal-title":"Bull World Health Organ"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T08:50:17Z","timestamp":1723539017000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,13]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/vox.13655"],"URL":"https:\/\/doi.org\/10.1111\/vox.13655","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"type":"print","value":"0042-9007"},{"type":"electronic","value":"1423-0410"}],"subject":[],"published":{"date-parts":[[2024,5,13]]}}}