{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:03:54Z","timestamp":1778846634901,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>A more restrictive blood donation criterion has been applied in Japan, with a maximum volume of whole blood (WB) donation of 400\u2009mL, allowing twice a year for female donors and thrice a year for male donors. However, iron deficiency was as high as 20.5% among female donors prior to donation, increasing to 37.7% after blood donation. More than 20\u2009years have passed since then, so we set out to investigate the present situation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 2659 (male\/female: 1496\/1163) donors of 400\u2009mL WB who gave informed consent to join the study were enrolled. Serum ferritin (sFer) of first\u2010time\/reactivated (FT\/RA) donors were compared with those of repeat donors, according to gender and age; those who returned for subsequent donations during the study period were also followed up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About one\u2010third of FT\/RA female donors had iron deficiency, possibly reflecting its high incidence among the general population. Interestingly, although sFer levels were low among pre\u2010menopausal FT\/RA female donors, these values were not much different in repeat donors, whereas significant differences were observed between FT\/RA and repeat donors among post\u2010menopausal females and in most age groups among males. As expected, donors with a normal initial sFer (\u226526\u2009ng\/mL) recovered faster than those with a low initial sFer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Female donors, especially, have iron deficiency even before donation, and the rate increased compared to what was found previously. Measures to prevent iron deficiency of blood donors is required, and studies are going on in Japan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13688","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:25:49Z","timestamp":1718349949000},"page":"912-920","source":"Crossref","is-referenced-by-count":6,"title":["Iron deficiency among Japanese whole\u2010blood donors measured by serum ferritin"],"prefix":"10.1111","volume":"119","author":[{"given":"Takeshi","family":"Odajima","sequence":"first","affiliation":[{"name":"Japanese Red Cross Central Blood Institute  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7619-6500","authenticated-orcid":false,"given":"Nelson H.","family":"Tsuno","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Central Blood Institute  Tokyo Japan"},{"name":"Japanese Red Cross Kanto\u2010Koshinetsu Block Blood Center  Tokyo 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