{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:52:31Z","timestamp":1787838751139,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Haemovigilance (HV) systems aim to improve transfusion outcomes in patients and donor safety. An important question for blood regulators is how to ensure an effective HV system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed the HV reports submitted to Paul\u2010Ehrlich\u2010Institut over the last two decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 2011 and 2020, 50.86\u2009million units of blood components were used, and 8931 suspected serious donor and recipient adverse reactions (SARs), 874 serious adverse events (SAEs) and 12,073 donor look\u2010backs were reported. Following implementation of specific risk\u2010minimization measures (RMMs) between 2000 and 2010, SAR reporting rates decreased for transfusion\u2010transmitted viral infections (TTVIs), transfusion\u2010related acute lung injury (TRALI) and transfusion\u2010transmitted bacterial infections (TTBIs), while increasing for other serious adverse transfusion reactions. Within this decade, the overall blood component use decreased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term data collection forms the basis to establish trends and changes in reporting and to evaluate the effect of RMM. Standardized criteria for reaction types, seriousness and imputability assessments and availability of a denominator are important elements. Central data collection and independent assessment allow for monitoring HV data in a nationwide context over time. Stakeholder involvement and transparent feedback on the benefit of RMM will help to achieve the objectives of HV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.13694","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T21:08:32Z","timestamp":1718744912000},"page":"953-962","source":"Crossref","is-referenced-by-count":4,"title":["A national surveillance system for continuous monitoring of blood transfusion safety: German haemovigilance data"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0674-9031","authenticated-orcid":false,"given":"Philipp","family":"Berg","sequence":"first","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarethe","family":"Heiden","sequence":"additional","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Witzenhausen","sequence":"additional","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-1386","authenticated-orcid":false,"given":"Gabriele","family":"Ruppert\u2010Seipp","sequence":"additional","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0271-2629","authenticated-orcid":false,"given":"Sarah","family":"Kehr","sequence":"additional","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-1276","authenticated-orcid":false,"given":"Markus B.","family":"Funk","sequence":"additional","affiliation":[{"name":"Division Safety of Biomedicines and Diagnostics Paul\u2010Ehrlich\u2010Institut (PEI)  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30200-5"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01313-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-833996"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-833988"},{"key":"e_1_2_9_6_1","volume-title":"Global status report on blood safety and availability 2021","author":"WHO","year":"2022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119665885.ch21"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2002.tb05271.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01442.x"},{"key":"e_1_2_9_11_1","volume-title":"A guide to establishing a national haemovigilance system","author":"WHO","year":"2016"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12582"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajts.ajts_192_20"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13291"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-021-07235-0"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12447"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12367"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15082"},{"key":"e_1_2_9_19_1","unstructured":"Directive 2002\/98\/EC of the European Parliament and of the Council of 27 January 2003 setting standards of quality and safety for the collection testing processing storage and distribution of human blood and blood components and amending Directive 2001\/83\/EC. 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