{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:40Z","timestamp":1787016040765,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objectives<\/jats:title>\n To explore transfusion\u2010related acute lung injury (TRALI) induced by human leucocyte antigen (HLA)\u2010II antibodies, and to analyse antibody typing and source.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n We retrospectively analysed the clinical symptoms and signs of two leukaemia patients with suspected TRALI from the same female donor. HLA phenotyping was performed on the two patients, the platelet donor, her husband and her two children. The HLA and human neutrophil antigen\u00a0antibodies in the donor's plasma were identified.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The clinical manifestations of two leukaemia patients were those of TRALI, and we treated them with timely ventilator support. A high titre of HLA\u2010II antibodies was in the plasma of the platelet donor. The antibodies were directed at HLA\u2010DRB3*03:01, HLA\u2010DRB1*09:01, HLA\u2010DRB1*12:02, HLA\u2010DRB3*01:01 and HLA\u2010DRB1*12:01:01G, which were specific to the HLA antigens of the two patients. High\u2010resolution HLA genotyping suggested that the donor's HLA\u2010II antibodies were derived from immune stimulation by the husband's antigens during pregnancy.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study described two cases of TRALI caused by HLA\u2010II antibodies from the same female donor. Appropriate management of blood donors with a history of multiple pregnancies is crucial.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/vox.13703","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T20:18:10Z","timestamp":1719433090000},"page":"1001-1005","source":"Crossref","is-referenced-by-count":3,"title":["Transfusion\u2010related acute lung injury induced by human leucocyte antigen\u2010\n II<\/scp>\n antibodies: Analysis of antibody typing and source"],"prefix":"10.1111","volume":"119","author":[{"given":"Zou","family":"Yu","sequence":"first","affiliation":[{"name":"Deyang People's Hospital Deyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Mao","sequence":"additional","affiliation":[{"name":"Deyang People's Hospital Deyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liao","family":"Xiuyun","sequence":"additional","affiliation":[{"name":"Deyang Central Blood Station Deyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3174-4845","authenticated-orcid":false,"given":"Jiang","family":"Tianhua","sequence":"additional","affiliation":[{"name":"Deyang People's Hospital Deyang Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15311"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000675"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02652.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2003.00352.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2015.68.2.101"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000214292.62276.8E"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2019.1640599"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181cc4d4b"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370932"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01941.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-860809"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.639976"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13817"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000187"},{"key":"e_1_2_10_16_1","first-page":"454","article-title":"Transfusion\u2010related acute lung injury (TRALI): a retrospective review of reported cases in Queensland, Australia over 20\u2009years","volume":"20","author":"Sivakaanthan A","year":"2022","journal-title":"Blood"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13703","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T23:11:40Z","timestamp":1727997100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,26]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1111\/vox.13703"],"URL":"https:\/\/doi.org\/10.1111\/vox.13703","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,26]]}}}