{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:08:39Z","timestamp":1790878119628,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","award":["APP1151959"],"award-info":[{"award-number":["APP1151959"]}],"id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003921","name":"Department of Health and Aged Care, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The risk of transfusion\u2010transmitted malaria (TTM) infections is extremely low in Australia, and the cost\u2010effectiveness of the current screening strategy has not been assessed. This study aims to conduct a cost\u2010effectiveness analysis of different malaria screening strategies in blood donors as part of the risk\u2010based decision\u2010making framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A decision tree model was developed to assess the cost\u2010effectiveness of five alternative malaria screening strategies from a healthcare sector perspective. Screening strategies combining total or partial removal of malaria testing with different deferral periods were considered. The probabilities of developing severe and uncomplicated TTM were based on a literature review of cases in non\u2010endemic areas since 2000. The health outcomes were quantified using disability\u2010adjusted life years. The costs of non\u2010returning donors due to deferral were also included. Deterministic and probabilistic sensitivity analyses were conducted to account for data uncertainty.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The residual risks for all strategies were so low that the costs, mortality and morbidity associated with TTM are almost negligible. The overall costs were predominantly influenced by the costs of non\u2010returning blood donors. As a result, removal of malaria testing and applying a 28\u2010day deferral for at\u2010risk donors were the least costly and most cost\u2010effective of all the options considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current screening strategy for malaria in blood donors in Australia is not an efficient use of healthcare resources. Partial or total removal of malaria testing would bring significant cost savings without significantly compromising blood safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13705","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:08:42Z","timestamp":1721866122000},"page":"936-944","source":"Crossref","is-referenced-by-count":3,"title":["Optimal malarial screening strategy in Australian blood donors: A cost\u2010effectiveness analysis"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3701-8760","authenticated-orcid":false,"given":"Qinglu","family":"Cheng","sequence":"first","affiliation":[{"name":"Kirby Institute UNSW Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-3661","authenticated-orcid":false,"given":"Veronica C.","family":"Hoad","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Melbourne Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8680-922X","authenticated-orcid":false,"given":"Peter","family":"Bentley","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Melbourne Australia"},{"name":"UWA Medical School The University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Harley","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Schenberg","sequence":"additional","affiliation":[{"name":"UWA Medical School The University of Western Australia  Perth Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Kirby Institute UNSW Sydney  Sydney Australia"},{"name":"Department of Global Health and Development London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Kirby Institute UNSW Sydney the Australian Red Cross Blood Service.Transfusion\u2010transmissible infections in Australia: 2020 surveillance report. 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