{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:08Z","timestamp":1747188488275,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1151959"],"award-info":[{"award-number":["APP1151959"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To reduce the risk of transfusion\u2010transmitted malaria (TTM) from transfusible components, Australia tests for malaria antibodies in both travellers returning from and former residents of malaria\u2010endemic areas. The testing is performed a minimum of 120\u2009days after last potential exposure. TTM is an extremely rare event and managing the risk adds considerable complexity. The objectives of this study were to analyse various testing and deferral strategies, considering the risk, donation numbers and operational complexities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A residual risk model was developed to calculate the risk of TTM in five testing\/deferral strategies. Australian blood donor data from 2020 and 2021 were used and incorporated the incidence of parasitaemia, <jats:italic>Plasmodium<\/jats:italic> species and the malaria enzyme immunoassay test's failure rate. Donor and donation loss or gain and an operational assessment were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The current model's estimated risk of TTM is 1 in 67.9\u2009million transfused units. Testing residents with a 120\u2010day plasma restriction for visitors without testing was found to have the same estimated risk, with an expected increase of 342 donations per year, significant cost savings and a 62% reduction in the number of donors requiring assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A strategy that involves testing residents of malaria areas only and a 120\u2010day plasma travel restriction would not significantly increase the risk of TTM, is operationally simpler, costs less and results in a small increase in donations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13706","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:08:20Z","timestamp":1721866100000},"page":"945-952","source":"Crossref","is-referenced-by-count":1,"title":["Managing the risk of transfusion\u2010transmitted malaria from Australian blood donations: Recommendation of a new screening strategy"],"prefix":"10.1111","volume":"119","author":[{"given":"Katia","family":"Schenberg","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7827-3661","authenticated-orcid":false,"given":"Veronica C.","family":"Hoad","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Melbourne Victoria Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Harley","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8680-922X","authenticated-orcid":false,"given":"Peter","family":"Bentley","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences University of Western Australia  Perth Western Australia Australia"},{"name":"Australian Red Cross Lifeblood  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_13_2_1","DOI":"10.30875\/6c551ba0-en"},{"doi-asserted-by":"publisher","key":"e_1_2_13_3_1","DOI":"10.5694\/j.1326-5377.2010.tb03590.x"},{"doi-asserted-by":"publisher","key":"e_1_2_13_4_1","DOI":"10.1093\/jtm\/taad164"},{"doi-asserted-by":"publisher","key":"e_1_2_13_5_1","DOI":"10.1111\/j.1423-0410.2005.00610.x"},{"doi-asserted-by":"publisher","key":"e_1_2_13_6_1","DOI":"10.1111\/trf.13080"},{"unstructured":"Alliance of Blood Operators.Risk based decision making for blood safety.2015. 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