{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:53:19Z","timestamp":1783338799108,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To investigate the prevalence, genotype and haematological characteristics of glucose\u20106\u2010phosphate dehydrogenase (<jats:styled-content style=\"fixed-case\">G6PD<\/jats:styled-content>) deficiency in the blood donor population of Wuxi area (Jiangsu Province, China) and to assess the impact of their red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) units on clinical transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We conducted genotyping and large\u2010scale screening for <jats:styled-content style=\"fixed-case\">G6PD<\/jats:styled-content> enzyme activity in the blood donors of Wuxi City. In addition, we assessed the haematological parameters of <jats:styled-content style=\"fixed-case\">G6PD<\/jats:styled-content>\u2010deficient and non\u2010deficient blood donors, and investigated the adverse transfusion reactions in patients transfused with <jats:styled-content style=\"fixed-case\">G6PD<\/jats:styled-content>\u2010deficient blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We investigated 17,113 blood donors, among whom 44 (0.26%) were tested positive for G6PD deficiency. We identified 40 G6PD gene variants, among which <jats:italic>c.1388G&gt;A, c.1376G&gt;T, c.1024C&gt;T<\/jats:italic> and <jats:italic>c.95A&gt;G<\/jats:italic> were common. In addition, we identified two novel <jats:italic>G6PD<\/jats:italic> gene variants, <jats:italic>c.1312G&gt;A<\/jats:italic> and <jats:italic>c.1316G&gt;A<\/jats:italic>. The G6PD\u2010deficient and non\u2010deficient blood samples showed a significant difference in the RBC, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), RBC distribution width, total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) values. However, the two samples showed no significant difference in the haemolysis rate at the end of the storage period. Finally, transfusion with G6PD\u2010deficient RBC units did not lead to any adverse transfusion reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The positive rate of G6PD deficiency in the blood donor population of Wuxi City is 0.26%, and the genetic variants identified in this population are consistent with the common genetic variants observed in the Chinese population. Blood centres can establish a database on G6PD\u2010deficient blood donors and mark their RBC units to avoid their use for special clinical patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13708","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T06:28:58Z","timestamp":1720247338000},"page":"1039-1046","source":"Crossref","is-referenced-by-count":3,"title":["Screening, genotyping and haematological analysis of glucose\u20106\u2010phosphate dehydrogenase deficiency in the blood donors of Wuxi City, China"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9197-8169","authenticated-orcid":false,"given":"Jianhuai","family":"Jin","sequence":"first","affiliation":[{"name":"Wuxi Blood Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wuxi Blood Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youshan","family":"Xu","sequence":"additional","affiliation":[{"name":"Wuxi Blood Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Wuxi Blood Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Sun","sequence":"additional","affiliation":[{"name":"Wuxi Blood Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wuxi Blood Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[{"name":"Wuxi Blood Center  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12068"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000944"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/17.14.5868"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407826-0.00004-7"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17756"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.10.003"},{"key":"e_1_2_9_8_1","first-page":"120","article-title":"G6PD\u2010deficient donor blood as a cause of hemolysis in two preterm infants","volume":"22","author":"Mimouni F","year":"1986","journal-title":"Isr J Med Sci"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-010-0039-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12096"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1179\/102453310X12583347010179"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13574"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.03.009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2065094"},{"key":"e_1_2_9_16_1","unstructured":"Chinese Society of Blood Transfusion (CSBT).Whole blood and component donor selection requirements. GB18467\u20102011. Available from:https:\/\/www.csbt.org.cn\/plus\/view.php?aid=68. Last accessed 20 Jan 2023."},{"key":"e_1_2_9_17_1","unstructured":"Chinese Society of Blood Transfusion (CSBT).Guideline for Haemovigilance. T\/CSBT 001\u20102019. Available from:https:\/\/dev.csbtweb.org.cn\/uploads\/soft\/190413\/3_0906391071.pdf. Last accessed 20 Jan 2023."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16554"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2527"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.07.068"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245330600938182"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959216"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-009-0005-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2022.2027082"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-020-03272-y"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4959518"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133530"},{"key":"e_1_2_9_28_1","volume-title":"Blood donor selection: guidelines on assessing donor suitability for blood donation","year":"2012"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T01:59:19Z","timestamp":1728439159000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/vox.13708"],"URL":"https:\/\/doi.org\/10.1111\/vox.13708","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]}}}