{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:58:17Z","timestamp":1788447497288,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Regular whole blood donations are associated with an increased risk of iron deficiency. Iron supplementation is an effective strategy to prevent donation\u2010induced iron deficiency. However, research on donor perceptions towards such a policy is limited. Therefore, we aim to evaluate donors' knowledge on donation\u2010induced iron depletion and their perceptions regarding iron supplementation as a blood service policy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Three thousand Dutch whole blood donors were invited to complete a survey assessing their knowledge of donation\u2010induced iron depletion and attitudes and perceptions towards iron supplementation as a policy. Linear regression modelling was used to evaluate associations between explanatory variables and perceptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1093 (77.1%) donors were included in the analysis. Donors had poor knowledge of current iron management policies, but a better understanding of iron metabolism and supplementation. Iron supplementation as a policy was perceived mainly positive by donors, and the majority were willing to use iron supplements if provided. Iron supplementation was not perceived as invasive or negatively affecting donors' motivation to continue donating. Additional iron monitoring, information and donor physician involvement were regarded as important conditions for implementation. Male sex, trust in the blood service, prior experience with iron supplements and openness towards dietary supplements were strongly positively associated with willingness to use iron supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Donors' knowledge regarding donation\u2010induced iron depletion is limited, but not associated with their perceptions regarding iron supplementation. Donors do not consider iron supplementation as invasive, deterring or demotivating, and a majority are willing to take supplements if offered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13712","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:28:51Z","timestamp":1720657731000},"page":"1047-1057","source":"Crossref","is-referenced-by-count":9,"title":["Donor knowledge and perceptions regarding donation\u2010induced iron depletion and iron supplementation as a blood service policy"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-4929","authenticated-orcid":false,"given":"Jan H. M.","family":"Karregat","sequence":"first","affiliation":[{"name":"Donor Studies, Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health (APH) Research Institute Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-9254","authenticated-orcid":false,"given":"Franke A.","family":"Quee","sequence":"additional","affiliation":[{"name":"Donor Studies, Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos W. R.","family":"Twisk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute Amsterdam UMC\u2013Location VU University Medical Centre  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-6003","authenticated-orcid":false,"given":"Katja","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Donor Studies, Department of Donor Medicine Research Sanquin Research  Amsterdam The Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam UMC  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health (APH) Research Institute Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310450030018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.441.441"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-020-04648-w"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"MeulenbeldA RamondtS SweegersMG QueeFA PrinszeFJ HoogendijkEO et al.Effectiveness of ferritin\u2010guided donation intervals in blood donors: results of the stepped wedge cluster\u2010randomised FIND'EM trial.medRxiv.2023https:\/\/doi.org\/10.1101\/2023.01.24.23284933","DOI":"10.1101\/2023.01.24.23284933"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15906"},{"key":"e_1_2_9_7_1","first-page":"20","article-title":"International forum: an investigation of iron status in blood donors","volume":"15","author":"Vuk T","year":"2017","journal-title":"Blood Transfus"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15676"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13547"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980017001707"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5688\/ajpe81592"},{"key":"e_1_2_9_12_1","unstructured":"Wet inzake bloedvoorziening.1997."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14984"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-056316"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16896"},{"key":"e_1_2_9_16_1","first-page":"1","article-title":"Low awareness of past SARS\u2010CoV\u20102 infection in healthy plasma donors","volume":"2","author":"Hurk K","year":"2021","journal-title":"Cell Rep Med"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/00131644231163813"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14226"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2006.04.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(02)00142-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1399.013"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.110.3.486"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0001-6918(91)90036-Y"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2018.06.032"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12641"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/NT.0000000000000119"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15179"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.10.002"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2013.7"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T01:59:01Z","timestamp":1728439141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/vox.13712"],"URL":"https:\/\/doi.org\/10.1111\/vox.13712","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]}}}