{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:02:31Z","timestamp":1775696551176,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LE 2498\/9\u20101"],"award-info":[{"award-number":["LE 2498\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p><jats:italic>Plasmodium<\/jats:italic> species are naturally transmitted by <jats:italic>Anopheles<\/jats:italic> mosquitos. The parasite infects red blood cells (RBCs) and can be transfused with blood products. In non\u2010endemic areas, the main risk of infection arises from travellers coming back and people immigrating from malaria\u2010endemic regions. Endemic countries face a permanent risk of infection from transfusion\u2010transmitted malaria (TTM). TTM may cause life\u2010threatening complications in patients dependent on blood donations. This study aimed to investigate the efficacy of <jats:italic>Plasmodium falciparum<\/jats:italic> inactivation in RBC units by treatment with short\u2010wavelength ultraviolet C (UVC) light in the absence of photochemical additives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>RBC units were spiked with <jats:italic>P. falciparum<\/jats:italic> to a parasite density of 0.1%\u20131% and irradiated with up to 4.5\u2009J\/cm<jats:sup>2<\/jats:sup> UVC. The parasite density of UVC\u2010treated dilution series and untreated controls were compared over 3\u2009weeks after irradiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lowest dose of 1.5\u2009J\/cm<jats:sup>2<\/jats:sup> UVC led to a 3.1 log reduction in parasite load compared with the untreated control. The inactivation capacity was dose\u2010dependent. Strikingly, 4.5\u2009J\/cm<jats:sup>2<\/jats:sup> led to \u22655.3 log unit reduction, which was equivalent to a complete inactivation in two out of three experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pathogen reduction with UVC light was previously shown to be effective for different bacteria and viruses, but the inactivation of parasites in RBC concentrates was not addressed until now. The present study provides evidence for significant inactivation of <jats:italic>P. falciparum<\/jats:italic>\u2010infected RBCs by UVC light.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13714","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:04:36Z","timestamp":1721865876000},"page":"1082-1089","source":"Crossref","is-referenced-by-count":3,"title":["Dose\u2010dependent inactivation of <i>Plasmodium falciparum<\/i> in red blood cell concentrates by treatment with short\u2010wavelength ultraviolet light"],"prefix":"10.1111","volume":"119","author":[{"given":"Swantje","family":"Fischer","sequence":"first","affiliation":[{"name":"Institute for Immunology University of Veterinary Medicine Hannover  Hanover Germany"},{"name":"Research Center for Emerging Infections and Zoonoses University of Veterinary Medicine Hannover  Hanover 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Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Gravemann","sequence":"additional","affiliation":[{"name":"DRK\u2010Blutspendedienst NSTOB, Institut Springe  Springe Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2181-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04301-8"},{"key":"e_1_2_9_4_1","volume-title":"World malaria report 2023","author":"World Health 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