{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:11Z","timestamp":1787016251450,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>There is a growing infectious syphilis outbreak in Western Canada. Although blood donors are screened for syphilis risks, some blood donors will still be confirmed test\u2010positive for syphilis. This study compares the characteristics of confirmed test\u2010positive syphilis donations in both Western Canada and Eastern Canada, November 2022\u2013August 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Donors were defined as Western or Eastern Canadian. Blood donations were tested for syphilis using the PK\u2010TP assay (Beckman Coulter PK7300 Automated Microplate System). Confirmatory\n                      <jats:italic>Treponema pallidum<\/jats:italic>\n                      particle agglutination (TPPA) and rapid plasma reagin (RPR) assays were performed by one of two reference laboratories. An RPR titre \u22651:8 was used as a proxy for possible infectious syphilis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Rates of laboratory\u2010confirmed syphilis were higher in Western (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943, 13.4\/100,000 donations) versus Eastern donors (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919, 4.7\/100,000 donations; Fisher's exact test, two\u2010sided,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.0001). Most syphilis confirmations were in first\u2010time donors (Western Canada\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200931\/43, 72.1%, Eastern Canada 12\/19, 63.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although rates of laboratory\u2010confirmed syphilis were higher in Western versus Eastern donors, Western donors did not have higher rates of infectious syphilis. Further studies might assess whether donors with laboratory\u2010confirmed syphilis understood pre\u2010donation screening questions or were completely unaware of a past infection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.13715","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T20:04:41Z","timestamp":1721851481000},"page":"1116-1121","source":"Crossref","is-referenced-by-count":3,"title":["Higher rates of laboratory\u2010confirmed cases of syphilis in Western Canadian blood donors compared with Eastern Canadian blood donors following a period of societal re\u2010opening"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-1109","authenticated-orcid":false,"given":"Steven J.","family":"Drews","sequence":"first","affiliation":[{"name":"Medical Microbiology, Donation Policy and Studies Canadian Blood Services  Edmonton Alberta Canada"},{"name":"Division of Diagnostic and Applied Microbiology, Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-5136","authenticated-orcid":false,"given":"Carmen","family":"Charlton","sequence":"additional","affiliation":[{"name":"Medical Microbiology, Donation Policy and Studies Canadian Blood Services  Edmonton Alberta Canada"},{"name":"Division of Diagnostic and Applied Microbiology, Laboratory Medicine and Pathology University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Tran","sequence":"additional","affiliation":[{"name":"Public Health Ontario  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Microbiology Provlab Alberta  Calgary Alberta Canada"},{"name":"Pathology and Laboratory Medicine University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Hawes","sequence":"additional","affiliation":[{"name":"Process Development, Infectious Diseases Testing Canadian Blood Services  Brampton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Resz","sequence":"additional","affiliation":[{"name":"Process Development, Blood Group Screening, Testing Canadian Blood Services  Brampton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2789","authenticated-orcid":false,"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance Canadian Blood Services, Donation Policy and Studies  Ottawa Ontario Canada"},{"name":"School of Epidemiology and Public Health, University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Government of Canada.Infectious syphilis and congenital syphilis in Canada 2022. CCDR. 2023; 49\u201010.https:\/\/www.canada.ca\/en\/public\u2010health\/services\/reports\u2010publications\/canada\u2010communicable\u2010disease\u2010report\u2010ccdr\/monthly\u2010issue\/2023\u201049\/issue\u201010\u2010october\u20102023\/infectious\u2010congenital\u2010syphilis\u2010canada\u20102022.html. Last accessed 18 Jun 2024."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v48i23a01"},{"key":"e_1_2_9_4_1","unstructured":"Canadian Blood Services.Surveillance report: 2019 2020 2021 2022. Available from:https:\/\/professionaleducation.blood.ca\/en\/transfusion\/publications\/surveillance-report. Last accessed 18 Jun 2024."},{"key":"e_1_2_9_5_1","unstructured":"Canadian Blood Services.Donor questionnaire for blood platelets and plasma. Available from:https:\/\/www.blood.ca\/en\/blood\/donating-blood\/donor-questionnaire. Last accessed 18 Jun 2024."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17878"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16786"},{"key":"e_1_2_9_8_1","unstructured":"Government of Canada.Syphilis guide: screening and diagnostic testing. Available from:https:\/\/www.canada.ca\/en\/public\u2010health\/services\/infectious\u2010diseases\/sexual\u2010health\u2010sexually\u2010transmitted\u2010infections\/canadian\u2010guidelines\/syphilis\/screening\u2010diagnostic\u2010testing.html#a2_2. Last accessed 18 Jun 2024."},{"key":"e_1_2_9_9_1","unstructured":"Statistics Canada.Canada and outside Canada\u2014sub\u2010areas. Available from:https:\/\/www23.statcan.gc.ca\/imdb\/p3VD.pl?Function=getVD&TVD=31553. Last accessed 18 Jun 2024."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00154-4"},{"key":"e_1_2_9_11_1","unstructured":"Government of Canada.Public health risk profile: infectious syphilis outbreaks and re\u2010emergence of congenital syphilis in Canada. Available from:https:\/\/www.canada.ca\/en\/public\u2010health\/services\/emergency\u2010preparedness\u2010response\/rapid\u2010risk\u2010assessments\u2010public\u2010health\u2010professionals\/risk\u2010profile\u2010infectious\u2010syphilis\u2010outbreaks\u2010emergence\u2010congenital\u2010syphilis.html. Last accessed 18 Jun 2024."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17393"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2024.102356"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17707"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2087"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16511"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00100-21"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-114-12-1005"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2024.01.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2023.103836"},{"key":"e_1_2_9_21_1","first-page":"80","article-title":"Serologic cross\u2010reactivity of syphilis, yaws, and pinta","volume":"87","author":"Caprariis PJ","year":"2013","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000196"},{"key":"e_1_2_9_23_1","first-page":"37","article-title":"Regional patterns of risk for sexually transmitted infections in British Columbia","volume":"21","author":"Deering KN","year":"2010","journal-title":"Health Rep"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v48i23a03"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16696"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T21:59:31Z","timestamp":1728424771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,24]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/vox.13715"],"URL":"https:\/\/doi.org\/10.1111\/vox.13715","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,24]]}}}