{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:06:12Z","timestamp":1792037172077,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>In Japan, apheresis donation of plasma is allowed to a maximum of 24 times a year, and plateletpheresis are counted as two plasmapheresis donations. Diversion of the initial blood flow is conducted for all donations, and additionally, blood remaining in apheresis machine circuit is lost. Here, we aimed to investigate on the health impact of frequent apheresis donations, as measured by the serum ferritin (sFer).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 538 male apheresis donors and 538 age\u2010matched whole blood (WB) donors, who gave informed consent to join the study, were enrolled. sFer were compared, according to age. Another group of 19 apheresis donors were followed during four consecutive donations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About half (48%) of repeat male apheresis donors had iron deficiency (sFer\u2009&lt;\u200926\u2009ng\/mL), compared with lower rates (13.9%) among male WB donors. It was evident in all age groups, except for teenagers, possibly because of the lower number of donations. Follow\u2010up of the 19 donors for 4\u2009months revealed a progressive decrease in sFer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Blood remaining in the apheresis machine circuit and diversion of the initial blood flow have been implicated in iron deficiency for many years. Taking the present results, the manufacturer of apheresis equipment was requested to improve it to allow rinseback of the remaining blood, which was achieved only for plateletpheresis. Until further improvement, plasmapheresis frequency was reduced to 12 times a year. Additional measures, such as oral supplementation of iron, need to be considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13720","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:03:29Z","timestamp":1723507409000},"page":"1141-1149","source":"Crossref","is-referenced-by-count":4,"title":["Repeated apheresis donations cause important iron deficiency in male Japanese donors"],"prefix":"10.1111","volume":"119","author":[{"given":"Takeshi","family":"Odajima","sequence":"first","affiliation":[{"name":"Japanese Red Cross Central Blood Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7619-6500","authenticated-orcid":false,"given":"Nelson H.","family":"Tsuno","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kanto\u2010Koshinetsu Block Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Fukuoka Red Cross Blood Center  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kyushu Block Blood Center  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6083","authenticated-orcid":false,"given":"Fumihiko","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Blood Service Headquarters, Technical Department  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Okubo","sequence":"additional","affiliation":[{"name":"Kanagawa Red Cross Blood Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Murakami","sequence":"additional","affiliation":[{"name":"Nagano Red Cross Blood Center  Nagano Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Kitsukawa","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kanto\u2010Koshinetsu Block Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Ikuta","sequence":"additional","affiliation":[{"name":"Hokkaido Red Cross Blood Center  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Muroi","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Kanto\u2010Koshinetsu Block Blood Center  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Satake","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Central Blood Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Kino","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Blood Services Headquarters  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03956.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03401.x"},{"key":"e_1_2_9_4_1","first-page":"33","article-title":"Storage iron levels in repeated apheresis donors","volume":"44","author":"Uchida T","year":"1998","journal-title":"Jap J Transfus 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