{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:24:10Z","timestamp":1782987850584,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Manual blood exchange (MBE) is a leukoreduction therapy for hyperleukocytosis in <jats:italic>Bordetella<\/jats:italic> spp. infection. We describe the impact of BE on clinical and biological parameters in critically ill children with malignant pertussis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This is a monocentric retrospective review of patients with malignant pertussis infection treated with MBE. It describes the evolution of haemodynamic, ventilatory, haematologic and metabolic characteristics before and after MBE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between January 2006 and December 2021, nine patients (median age 43\u2009days, range: 13\u201380\u2009days) had 16 MBE for malignant pertussis. All patients were mechanically ventilated, and 7\/9 patients developed pulmonary hypertension during their paediatric intensive care unit (PICU) stay. Overall, 3\/9 patients survived, and the mean PICU length of stay was 8.5\u2009days (range: 1\u201352\u2009days). We found a significant reduction of the leukocyte count (pre\u2010MBE: 61.8\u2009G\/L [interquartile range (IQR): 55.8\u201374.8] vs. post\u2010MBE: 19.4\u2009G\/L [IQR: 17.7\u201324.1]; <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001) and significant oxygenation improvement (pre\u2010MBE SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>: 190 [IQR: 106\u2013200] vs. post\u2010MBE SpO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub>: 242 [IQR: 149\u2013250]; <jats:italic>p\u2009=<\/jats:italic>\u20090.03). The main side effects were a significant reduction of thrombocytes (pre\u2010MBE: 411\u2009G\/L [IQR: 166.5\u2013563.5] vs. post\u2010MBE: 66\u2009G\/L [IQR: 46\u201382.5]; <jats:italic>p\u2009=<\/jats:italic>\u2009&lt;0.001) and of ionized calcium (iCa) (pre\u2010MBE iCa: 1.3 [IQR: 1.22\u20131.37] vs. post\u2010MBE iCa: 1.25 [IQR: 1.85\u20132.24]; <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MBE efficiently reduces leukocytes and improves oxygenation in severe <jats:italic>Bordetella pertussis<\/jats:italic> infection in infants. Careful monitoring of calcium and thrombocytes seems mandatory.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13722","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:10:20Z","timestamp":1723594220000},"page":"1191-1195","source":"Crossref","is-referenced-by-count":7,"title":["Biological impact of manual blood exchange in malignant <i>Bordetella pertussis<\/i> infection in infants"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5729-671X","authenticated-orcid":false,"given":"Vladimir L.","family":"Cousin","sequence":"first","affiliation":[{"name":"Pediatric Critical Care, Neonatal Medicine and Emergency AP\u2010HP Paris Saclay University, Bic\u00eatre Hospital  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Pediatric Intensive Care Unit, Department of Pediatrics, Gynecology and Obstetrics Geneva University Hospital  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Caula","sequence":"additional","affiliation":[{"name":"Pediatric Emergency H\u00f4pital Robert\u2010Debr\u00e9, Assistance Publique des H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-5532","authenticated-orcid":false,"given":"Pierre","family":"Tissi\u00e8res","sequence":"additional","affiliation":[{"name":"Pediatric Critical Care, Neonatal Medicine and Emergency AP\u2010HP Paris Saclay University, Bic\u00eatre Hospital  Le Kremlin\u2010Bic\u00eatre France"},{"name":"Institute of Integrative Biology of the Cell, CNRS, CEA Paris Saclay University  Gif\u2010sur\u2010Yvette France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.4.1900762"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcped.2014.10.010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e31828a70fe"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000265499.50592.37"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-021-00856-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001013"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000577"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation.V2012.1.475.3798515"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftw087"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/589753"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2860"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13085"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:20:14Z","timestamp":1731543614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,13]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/vox.13722"],"URL":"https:\/\/doi.org\/10.1111\/vox.13722","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,13]]}}}