{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:59:34Z","timestamp":1774353574162,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Human platelet antigens (HPA) play a central role in foetal and neonatal alloimmune thrombocytopenia (FNAIT), post\u2010transfusion purpura and some cases of platelet therapy refractoriness. The frequency distribution of HPA had not been studied in the Greek population before we started to create a registry of HPA\u2010typed apheresis platelet donors. The aim of this study was the determination of the frequency of various HPA in the Greek population, through the establishment of a registry of typed donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Here, we report on the first 1000 platelet donors of Greek origin who gave informed consent and were genotyped for 12 pairs of antithetical HPA by Single Specific Primer\u2010Polymerase Chain Reaction (SSP\u2010PCR), including HPA\u20101, HPA\u20103, HPA\u20105 and HPA\u201015. Antigen frequencies are reported, and allele frequencies were calculated and compared with other European and non\u2010European populations. Tested donors cover all ABO and Rhesus D antigen spectrum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antigen and allele frequencies are very similar to other White populations. The frequency of HPA\u20101bb is 2.9% in our study, and the frequency of HPA\u20102b, HPA\u20104b, HPA\u20109b and HPA\u201015b is also slightly higher than in other literature reports, while the frequency of HPA\u201015b was found higher than that of HPA\u201015a.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report antigen and allele frequencies for a large array of clinically significant HPA for the first time in the Greek population. Frequencies are consistent with other European populations. This registry of HPA\u2010typed platelet donors, available to donate on demand, is an important asset for the treatment of FNAIT cases in Greece.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13739","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T03:14:04Z","timestamp":1727147644000},"page":"1295-1300","source":"Crossref","is-referenced-by-count":2,"title":["Frequency of human platelet antigens (<scp>HPA<\/scp>) in the Greek population as deduced from the first registry of <scp>HPA<\/scp>\u2010typed blood donors"],"prefix":"10.1111","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8803-9273","authenticated-orcid":false,"given":"Georgios","family":"Kaltsounis","sequence":"first","affiliation":[{"name":"Blood Center AHEPA University General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evangelia","family":"Boulomiti","sequence":"additional","affiliation":[{"name":"Blood Center AHEPA University General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitroula","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Blood Center AHEPA University General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-4752","authenticated-orcid":false,"given":"Dimitrios","family":"Stoimenis","sequence":"additional","affiliation":[{"name":"Blood Center AHEPA University General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotios","family":"Girtovitis","sequence":"additional","affiliation":[{"name":"Blood Center AHEPA University General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Hasapopoulou\u2010Matamis","sequence":"additional","affiliation":[{"name":"Blood Center AHEPA University General Hospital of Thessaloniki  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12085"},{"key":"e_1_2_9_3_1","unstructured":"Versiti.Human platelet antigen (HPA) database. Available from:https:\/\/versiti.org\/products\u2010services\/human\u2010platelet\u2010antigen\u2010hpa\u2010database. Last accessed 1 Aug 2024."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2003.00331.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb02085.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(90)70254-4"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V83.6.1447.1447"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1998.tb05427.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(13)70020-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(02)00063-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.102704"},{"key":"e_1_2_9_12_1","first-page":"168","volume-title":"Principles and practice of screening for disease","author":"Wilson J","year":"1968"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.050112"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb08341.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2008.00899.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2008.0060"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12235"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2019.01.017"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(89)90002-7"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02198.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13597"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.09.010"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07189.x"},{"key":"e_1_2_9_24_1","first-page":"525","volume-title":"Manual of American Association of Blood Banks","author":"Stroncek D","year":"2020"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2010.00958.x"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02657.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.63600"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3320"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7806"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e3182947ce4"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(92)90036-M"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03734.x"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12663"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T23:50:20Z","timestamp":1733961020000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,23]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/vox.13739"],"URL":"https:\/\/doi.org\/10.1111\/vox.13739","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,23]]}}}