{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:46:27Z","timestamp":1788345987508,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012023","name":"Stichting Sanquin Bloedvoorziening","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Foetal and neonatal alloimmune thrombocytopenia (FNAIT) results from maternal platelet\u2010directed antibodies and can result in severe intracranial haemorrhage (ICH) in foetuses and newborns. Screening for human platelet antigen\u20101a (HPA\u20101a)\u2010directed antibodies during pregnancy could allow timely intervention with antenatal treatment and prevent ICH. We assessed the cost effectiveness of HPA\u20101a typing and anti\u2010HPA\u20101a\u2010screening as part of the prenatal screening programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Different HPA\u20101a screening scenarios were tested in a decision analysis model and assessed for diagnostic, treatment, intervention and lifetime costs and prevention effects compared to the current situation without screening in the Netherlands. Model parameters were based on available data, literature and expert opinions. One\u2010way sensitivity analysis and probabilistic sensitivity analysis were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adding screening for anti\u2010HPA\u20101a antibodies to the current antenatal screening programme of the Netherlands will lead to an additional cost of \u20ac4.7\u2009million per year and a gain of 226 quality\u2010adjusted life years (QALYs) per year, indicating an incremental cost\u2013effectiveness ratio (ICER) of \u20ac20,782 per QALY gained. One\u2010way sensitivity analysis showed that the uncertainty around the incidence of ICH, lifetime costs of disabled children and the probability of having antibody quantitation &gt;3.0\u2009IU\/mL at 20\u2009weeks had the highest effect on the ICER.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antenatal anti\u2010HPA\u20101a screening might be cost effective. To obtain more knowledge and thereby to improve risk stratification, a pilot screening programme is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13779","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T02:40:16Z","timestamp":1733452816000},"page":"178-187","source":"Crossref","is-referenced-by-count":11,"title":["Screening of pregnant women for foetal neonatal alloimmune thrombocytopenia: A cost\u2013utility analysis"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3653-3234","authenticated-orcid":false,"given":"Thijs W.","family":"de Vos","sequence":"first","affiliation":[{"name":"Willem\u2010Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology Leiden University Medical Center  Leiden the Netherlands"},{"name":"Department of Experimental Immunohematology Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilonka","family":"Tersteeg","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences, Section Medical Decision Making Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Willem\u2010Alexander Children's Hospital, Department of Pediatrics, Division of Neonatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leendert","family":"Porcelijn","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Ellen","family":"van der Schoot","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology Sanquin Research  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Joanne T.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dian","family":"Winkelhorst","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology Sanquin Research  Amsterdam the Netherlands"},{"name":"Department of Obstetrics and Gynecology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-0525","authenticated-orcid":false,"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunohematology Sanquin Research  Amsterdam the Netherlands"},{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam the Netherlands"},{"name":"Department of Hematology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Elske","family":"van den Akker\u2010van Marle","sequence":"additional","affiliation":[{"name":"Department of Biomedical Data Sciences, Section Medical Decision Making Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04026.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283317be9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2008.04.010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-034071"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000415163"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994382"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00645.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01289.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(23)00271-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.11.041"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015666"},{"key":"e_1_2_9_13_1","first-page":"3","article-title":"Fetal intracranial haemorrhages caused by fetal and neonatal alloimmune thrombocytopenia: an observational cohort study of 43 cases from an international multicentre registry","author":"Tiller H","year":"2013","journal-title":"BMJ Open"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2280"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-040121"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12515"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-016-0431-y"},{"key":"e_1_2_9_18_1","unstructured":"van derPloegCPB OomenP vanLentM.Prenatale Screening Infectieziekten en Erytrocytenimmunisatie (PSIE).2021.https:\/\/www.pns.nl\/documenten\/proces-monitor-psie-2021"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488280"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02068.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02657.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17731"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00243-5"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.05.063"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002137"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001894"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12731"},{"key":"e_1_2_9_28_1","unstructured":"Diagnostics S.Foetale HPA\u20101a genotypering in maternaal plasma \u2013 Diagnostische testen. 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