{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:26:07Z","timestamp":1765423567200,"version":"3.40.2"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Restless legs syndrome (RLS), with adverse health outcomes, has been linked to blood donation, but evidence published thus far has not been rigorously analysed. This systematic review aggregates existing evidence on RLS among blood donors and identifies associated factors worthy of further investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>MEDLINE and EMBASE were searched for articles published through 16 December 2023. Eleven studies from eight countries were selected from 142 publications. The pooled prevalence of RLS was calculated using a random\u2010effects model, with heterogeneity assessed by the Cochran <jats:italic>Q<\/jats:italic> and <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> statistics. Meta\u2010regression and sensitivity analyses explored sources of heterogeneity and the robustness of findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven studies, involving 20,255 blood donors, were included. The pooled prevalence of RLS among blood donors was 10.30% (95% confidence interval [CI]: 5.54%\u201316.30%), which was significantly higher than in the general adult population (3.0%, 95% CI: 1.4%\u20133.8%). Meta\u2010regression identified the year of study and geographical region as significant sources of heterogeneity. From the five studies that used logistic regression analyses, female sex and older age stand out as associated factors. No publication bias was detected, and sensitivity analysis confirmed the robustness of results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest a high burden of RLS among blood donors, underscoring the need for further research with standardized criteria, appropriate design and analytical methodologies to better understand the impact of RLS on individual donors and the global blood supply.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13780","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:29:20Z","timestamp":1733876960000},"page":"246-255","source":"Crossref","is-referenced-by-count":2,"title":["Restless legs syndrome among blood donors: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"120","author":[{"given":"Alain M.","family":"Ngoma","sequence":"first","affiliation":[{"name":"Centre int\u00e9gr\u00e9 de sant\u00e9 et de services sociaux de l'Outaouais  Gatineau Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulin B.","family":"Mutombo","sequence":"additional","affiliation":[{"name":"Kinshasa School of Public Health University of Kinshasa  Kinshasa Democratic Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Mosli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine King Abdulaziz University  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magot D.","family":"Omokoko","sequence":"additional","affiliation":[{"name":"Department of Medicine, FMSS Sherbrooke University  Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E.","family":"Nollet","sequence":"additional","affiliation":[{"name":"Radiation Medical Science Center for the Fukushima Health Management Survey Fukushima Medical University  Fukushima Japan"},{"name":"Department of Blood Transfusion and Transplantation Immunology Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0340-883X","authenticated-orcid":false,"given":"Hitoshi","family":"Ohto","sequence":"additional","affiliation":[{"name":"Radiation Medical Science Center for the Fukushima Health Management Survey Fukushima Medical University  Fukushima Japan"},{"name":"Department of Blood Transfusion and Transplantation Immunology Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2012.08.004"},{"key":"e_1_2_9_3_1","first-page":"539","article-title":"The frequency and impact of restless legs syndrome in primary care","volume":"100","author":"O'Keeffe ST","year":"2007","journal-title":"Ir Med J"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440030025004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(04)90136-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.02.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01862.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.11.1286"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.12.018"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp060031"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13783"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310450030018"},{"key":"e_1_2_9_13_1","first-page":"453","article-title":"Therapy in restless legs","volume":"145","author":"Norlander NB","year":"1953","journal-title":"Acta Med Scand"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/21.4.381"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.11.014"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12270"},{"key":"e_1_2_9_17_1","unstructured":"SchwarzerG.Meta: Meta\u2010Analysis with R. 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