{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:15Z","timestamp":1787016255413,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000038","name":"Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>\n                      Malaria risk deferral policies are important for mitigating the risk of transfusion\u2010transmitted malaria and apply to all transfusable components, including plasma. While donors of plasma components are deferred for malaria risk in the United States, the viability of intraerythrocytic\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      parasites present in human plasma components stored under different temperatures and durations has not been previously reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      We spiked human plasma with a low level of ring\u2010stage\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      \u2010infected red blood cells and then determined their viability in cultures after storage at room temperature (22\u00b0C), refrigeration (4\u00b0C) and frozen conditions at \u221220 and \u221280\u00b0C.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      parasites spiked in human plasma remained viable after storage at 22\u00b0C for a maximum of 7\u2009days. When stored at 4\u00b0C, parasites were viable after 1 and 3\u2009days of storage and only for 1\u2009day after storage at \u221220\u00b0C. Storage at \u221280\u00b0C had a cryopreserving effect and parasites remained viable for up to 176\u2009days, the longest period tested.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      parasites can survive for short durations in human plasma when stored at room temperature, or in refrigerated or frozen conditions at \u221220\u00b0C. However, when stored at \u221280\u00b0C, viable parasites were detected for up to 176\u2009days, the maximum duration for which viability was assessed. In summary,\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      parasites can survive in human plasma under different storage conditions and pose a risk of transfusion\u2010transmitted infection.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.13781","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T02:21:05Z","timestamp":1733970065000},"page":"149-154","source":"Crossref","is-referenced-by-count":5,"title":["Viability of\n                    <i>Plasmodium falciparum<\/i>\n                    parasites in human plasma under different storage conditions"],"prefix":"10.1111","volume":"120","author":[{"given":"Anna","family":"Lavrentieva","sequence":"first","affiliation":[{"name":"Office of Blood Research and Review Center for Biologics Evaluation and Review, Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda S.","family":"Oakley","sequence":"additional","affiliation":[{"name":"Office of Blood Research and Review Center for Biologics Evaluation and Review, Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford T. H.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Office of Blood Research and Review Center for Biologics Evaluation and Review, Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria F.","family":"Majam","sequence":"additional","affiliation":[{"name":"Office of Blood Research and Review Center for Biologics Evaluation and Review, Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-626X","authenticated-orcid":false,"given":"Anne F.","family":"Eder","sequence":"additional","affiliation":[{"name":"Office of Blood Research and Review Center for Biologics Evaluation and Review, Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-4751","authenticated-orcid":false,"given":"Carlos H.","family":"Villa","sequence":"additional","affiliation":[{"name":"Office of Blood Research and Review Center for Biologics Evaluation and Review, Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6375-9354","authenticated-orcid":false,"given":"Sanjai","family":"Kumar","sequence":"additional","affiliation":[{"name":"Office of Blood Research and Review Center for Biologics Evaluation and Review, Food and Drug Administration  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.World Malaria Report 2023. Available URL:https:\/\/iris.who.int\/bitstream\/handle\/10665\/374472\/9789240086173\u2010eng.pdf. Last accessed Dec 6 2024.\u00a0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7108a1"},{"key":"e_1_2_9_4_1","first-page":"412","article-title":"Multifocal autochthonous transmission of malaria\u2014Florida, 2003","volume":"53","author":"Selover C","year":"2004","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7236a1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7241a3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106283442603"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piab083"},{"key":"e_1_2_9_9_1","first-page":"159","volume-title":"Screening blood donors with the donor history questionnaire","author":"Katz LM","year":"2019"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14778"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290210067033"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-194308000-00001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92641-3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16196"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000629"},{"key":"e_1_2_9_16_1","unstructured":"GandhiM.Development of a Standardized Visual Inspection Aid for Plasma. Available from:https:\/\/news.mayocliniclabs.com\/2018\/12\/04\/development\u2010of\u2010a\u2010standardized\u2010visual\u2010inspection\u2010aid\u2010for\u2010plasma\/. Last accessed 9 Sep 2024."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02079.x"},{"key":"e_1_2_9_18_1","volume-title":"Guide for the preparation, use and quality assurance of blood components: recommendation no. 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Last accessed 9 Sep 2024."}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T23:09:49Z","timestamp":1740092989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/vox.13781"],"URL":"https:\/\/doi.org\/10.1111\/vox.13781","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}