{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:38:19Z","timestamp":1783841899112,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Cold\u2010stored whole blood (CS\u2010WB) in paediatric cardiac surgery is making a resurgence, given its identified benefits compared to conventional blood component therapy (CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>A single\u2010centre retrospective study was conducted from January 2018 to October 2018 by including children &lt;18\u2009years of age undergoing cardiac surgery requiring cardiopulmonary bypass. ABO\u2010compatible CS\u2010WB from non\u2010directed random donors was leukoreduced with platelet\u2010sparing filters and compared with CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven patients (30, 53% CS\u2010WB; 27, 47% CT) were studied. Patient demographics were similar, although CT patients were cooled to a lower intra\u2010operative temperature. Blood product requirements 24\u2009h post operation were less in the CS\u2010WB group (11.1 vs. 26.7\u2009mL\/kg, <jats:italic>p<\/jats:italic>\u2009=\u20090.048). Twelve (40%) patients in the CS\u2010WB cohort had more than one donor exposure versus 25 (93%) in the CT group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). CT patients compared to CS\u2010WB patients had a greater decrease in pre\u2010operative versus 48\u2010h post\u2010operative haemoglobin, platelets and prothrombin time. Patients who received CT compared to CS\u2010WB had a trend towards higher median (interquartile range [IQR]) chest\u2010tube output (mL\/kg\/h) in the first 4\u2009h post cardiac intensive care unit (ICU) admission (2.1 [0.8, 3] vs. 1.6 [0.8, 2.2], <jats:italic>p<\/jats:italic>\u2009=\u20090.197). There was no difference in antifibrinolytic use, length of stay, sepsis, acute kidney injury or wound infection. Survival to discharge was similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CS\u2010WB in paediatric cardiac surgery may reduce donor exposure and improve haemostatic balance. Future multi\u2010centre prospective studies are needed to validate these findings and identify patients who would benefit from CS\u2010WB in paediatric cardiac surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13786","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:28:06Z","timestamp":1734654486000},"page":"293-300","source":"Crossref","is-referenced-by-count":1,"title":["Forty\u2010eight\u2010hour cold\u2010stored whole blood in paediatric cardiac surgery: Implications for haemostasis and blood donor exposures"],"prefix":"10.1111","volume":"120","author":[{"given":"Amy L.","family":"Kiskaddon","sequence":"first","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Institute for Clincial and Translational Research, Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"},{"name":"Department of Pharmacy Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"},{"name":"Heart Institute Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3801-4198","authenticated-orcid":false,"given":"Jennifer","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology &amp; Immunology Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Pediatrics Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Oncology Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Department of Pathology Johns Hopkins University School of Medicine  Baltimore Maryland 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vyas","family":"Kartha","sequence":"additional","affiliation":[{"name":"Heart Institute Johns Hopkins All Children's Hospital  St. Petersburg Florida USA"},{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-7414","authenticated-orcid":false,"given":"Nhue L.","family":"Do","sequence":"additional","affiliation":[{"name":"Advocate Children's Heart Institute Advocate Children's Hospital  Chicago Illinois USA"},{"name":"Chicagoland Children's Health Alliance  Chicago Illinois 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