{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:25:01Z","timestamp":1770823501434,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>To determine whether intra\u2010individual differences in pre\u2010donation blood test results were associated with vasovagal reactions (VVRs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study included donors who voluntarily donated 400\u2009mL of whole blood at least twice during a 5\u2010year blood collection period of the Japanese Red Cross, including both donations with and without a VVR. A conditional logistic regression analysis by age group and sex was conducted, using each donor as a stratum, together with an analysis of deviance to test the significance of including an interaction term between age group and blood data in the regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1873 donors were included in the analysis. Haemoglobin, haematocrit, total protein and albumin values prior to donation were higher when a VVR was observed than when it was not for each age group and sex. The regression analysis showed significant positive associations between each of these blood parameters and VVR in all combinations of age groups and sex. A particularly strong positive association between haemoglobin and VVRs is seen in women aged \u226550\u2009years (odds ratio, OR [95% confidence interval, CI]: 1.844 [1.457, 2.333]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Haemoglobin, haematocrit, total protein and albumin levels within individual donors were significantly higher at donation with a VVR. This was most notable in women aged \u226550\u2009years. Comparing the pre\u2010donation haemoglobin value with past values in the same donor at the donation site would help raise awareness of the risk of VVRs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13787","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T02:59:42Z","timestamp":1735873182000},"page":"260-267","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between blood test results and vasovagal reactions: An intra\u2010individual comparative retrospective analysis of blood donor data in Japan"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2726-2843","authenticated-orcid":false,"given":"Taeko","family":"Chijiiwa","sequence":"first","affiliation":[{"name":"Fukuoka Red Cross Blood Centre  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akie","family":"Hirata","sequence":"additional","affiliation":[{"name":"Medical Information Centre, Kyushu University Hospital  Fukuoka Japan"},{"name":"Department of Medical Informatics, Faculty of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasuku","family":"Okui","sequence":"additional","affiliation":[{"name":"Medical Information Centre, Kyushu University Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Fukuoka Red Cross Blood Centre  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Medical Information Centre, Kyushu University Hospital  Fukuoka Japan"},{"name":"Department of Medical Informatics, Faculty of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Kumagawa","sequence":"additional","affiliation":[{"name":"Fukuoka Red Cross Blood Centre  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.19.2279"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01519.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00905.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2003.08.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2005.02.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03551.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01409.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02288.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03216.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01600.x"},{"key":"e_1_2_9_12_1","unstructured":"Japanese Red Cross Society Blood donation Consent Form Ver 5. 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