{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:10Z","timestamp":1787016070354,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018853","name":"Common Good","doi-asserted-by":"publisher","award":["MS2014\u201050"],"award-info":[{"award-number":["MS2014\u201050"]}],"id":[{"id":"10.13039\/501100018853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Randomized controlled trials have demonstrated morbidity and mortality in critically ill patients are unaffected by transfusing fresh (&lt;7\u2009days old) packed red blood cells (pRBCs); however, there is limited evidence regarding transfusion with pRBCs nearing expiry (35\u201342\u2009days). The aim of this study was to investigate the effects of transfusing pRBCs close to the end of shelf life (\u226535\u2009days) on clinical outcomes in critically ill patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A retrospective observational analysis of data obtained from centralized electronic medical records (2007\u20132013), sourced from all public and licensed private hospitals in Queensland, Australia, with intensive care units. Multivariate logistic and linear regressions were used to analyse association between transfusion with pRBCs nearing expiry, and in\u2010hospital mortality, hospital length of stay (HLOS) and rate of discharge home. Comparisons are presented as odds ratios (ORs) with 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 10,350 critically ill adult patients transfused \u22651 unit of non\u2010irradiated pRBCs (64,594 pRBCs units transfused). Receiving at least 1\u2010unit pRBCs\u2009\u2265\u200935\u2009days old was associated with increased mortality (OR 1.21 [95% CI 1.06\u20131.38];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), decreased discharge to usual residence (OR 0.81 [95% CI 0.73\u20130.89];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and increased hospital LOS (estimate 2.55 [95% CI 1.60\u20133.49];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). There was also association with increased sepsis (OR 1.27 [95% CI 1.13\u20131.42];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) and delirium (OR 1.25 [95% CI 1.06\u20131.49];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Transfusion of \u22651\u2010unit pRBCs\u2009\u2265\u200935\u2009days old was associated with higher morbidity and mortality in critically ill patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70007","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T18:26:28Z","timestamp":1741458388000},"page":"481-489","source":"Crossref","is-referenced-by-count":5,"title":["Effects of transfusing older red blood cells on patient outcomes in critical illness: A retrospective cohort study"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-4359","authenticated-orcid":false,"given":"Nchafatso G.","family":"Obonyo","sequence":"first","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"},{"name":"Initiative to Develop African Research Leaders (IDeAL)\/KEMRI\u2010Wellcome Trust Research Programme  Kilifi Kenya"},{"name":"Wellcome Trust Centre for Global Health Research Imperial College London  London UK"},{"name":"Faculty of Health Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan P.","family":"Sela","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"White","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Australian Centre for Health Services Innovation and Centre for Healthcare Transformation, School of Public Health and Social Work Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tunbridge","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Sim","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reema H.","family":"Rachakonda","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise E.","family":"See Hoe","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"},{"name":"School of Pharmacy and Medical Sciences Griffith University  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Li Bassi","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"},{"name":"Faculty of Health Queensland University of Technology  Brisbane Queensland Australia"},{"name":"Wesley Medical Research The Wesley Foundation  Brisbane Queensland Australia"},{"name":"Intensive Care Unit St Andrew's War Memorial Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon P.","family":"Fanning","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"},{"name":"Nuffield Department of Population Health University of Oxford  Oxford UK"},{"name":"Division of Cardiac Surgery, Department of Surgery Johns Hopkins School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John\u2010Paul","family":"Tung","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"},{"name":"Faculty of Health Queensland University of Technology  Brisbane Queensland Australia"},{"name":"Clinical Services and Research Australian Red Cross Lifeblood  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky Y.","family":"Suen","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Critical Care Research Group The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"Institute for Molecular Bioscience University of Queensland  Brisbane Queensland Australia"},{"name":"Faculty of Health Queensland University of Technology  Brisbane Queensland Australia"},{"name":"Intensive Care Unit St Andrew's War Memorial Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine Griffith University  Gold Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.191932"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2008.01097.x"},{"key":"e_1_2_9_4_1","first-page":"s7","article-title":"Time to revisit red blood cell additive solutions and storage conditions: a role for \u201comics\u201d analyses","volume":"10","author":"Sparrow RL","year":"2012","journal-title":"Blood Transfus"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91309"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.04.006"},{"key":"e_1_2_9_7_1","first-page":"27","article-title":"Red blood cell storage lesion: causes and potential clinical consequences","volume":"17","author":"Yoshida T","year":"2019","journal-title":"Blood 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Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:40:00Z","timestamp":1748374800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/vox.70007"],"URL":"https:\/\/doi.org\/10.1111\/vox.70007","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]}}}