{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T17:01:00Z","timestamp":1754154060081,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017571","name":"Fiona Stanley Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>Background and Objectives<\/jats:title>Iron deficiency anaemia is common in patients recovering from major surgery and is associated with poorer post\u2010operative outcomes. We designed a randomized controlled trial treating post\u2010operative anaemia with iron therapy to observe the influence on post\u2010operative recovery.<\/jats:p><\/jats:sec>Materials and Methods<\/jats:title>Anaemic patients (haemoglobin [Hb]\u2009<\u2009120\u2009g\/L for women, Hb\u2009<\u2009130\u2009g\/L for men) recovering from major abdominal surgery at Fiona Stanley Hospital were recruited. Patients were double\u2010blind randomized 1:1 to ferric carboxymaltose (FCM) or saline administered 4\u2009weeks post\u2010discharge and included in a 12\u2010week exercise programme. Iron indices, quality of life (QoL) questionnaires and muscle function tests were conducted at 4\u2009weeks (baseline), 8\u2010, 12\u2010 and 16\u2010weeks post\u2010discharge. This pilot study primarily aimed to assess the feasibility of recruiting 20 patients per intervention arm. Trial registration: ACTRN12622001447741.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 205 eligible patients screened between 5 May 2023 and 31 August 2023, only four patients were recruited, of which one completed the study. After randomization to FCM, results obtained from the sole participant that completed the trial suggested a trend towards improvement in QoL outcomes, Hb and muscle function.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Recruitment to a randomized controlled trial exploring the influence of iron therapy on muscle function after major abdominal surgery was not feasible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.70037","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T23:04:52Z","timestamp":1745363092000},"page":"678-682","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of conducting a randomized controlled trial to explore the muscular influence of post\u2010operative intravenous iron treatment for anaemia after major abdominal surgery"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5346-7673","authenticated-orcid":false,"given":"Beth","family":"MacLean","sequence":"first","affiliation":[{"name":"School of Medicine The University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert U.","family":"Newton","sequence":"additional","affiliation":[{"name":"Exercise Medicine Research Institute Edith Cowan University Perth Australia"},{"name":"School of Human Movement and Nutrition Sciences University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Western Australia Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"Richards","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Western Australia Perth Australia"},{"name":"School of Health, Sport and Bioscience University of East London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2023.10.003"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.12.013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11144222"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278481"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.207"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11148"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.1999.0121"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.2.568S"},{"key":"e_1_2_9_10_1","first-page":"281","article-title":"The myoglobin content of human skeletal muscle","volume":"25","author":"Boulton FE","year":"1973","journal-title":"Br J Haematol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00246.2003"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T23:30:10Z","timestamp":1753313410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":10,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/vox.70037"],"URL":"https:\/\/doi.org\/10.1111\/vox.70037","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"type":"print","value":"0042-9007"},{"type":"electronic","value":"1423-0410"}],"subject":[],"published":{"date-parts":[[2025,4,22]]}}}