{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:11:21Z","timestamp":1756339881902,"version":"3.44.0"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ECTZ190332"],"award-info":[{"award-number":["ECTZ190332"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Hepatitis B virus (HBV) is the virus transmissible by transfusion in Cameroon with highest prevalence. The benefit of pre\u2010donation screening (PDS) versus post\u2010donation testing (PDT) remains to be confirmed because of controversial results produced by the use of different methodologies. This study aims to compare the performance and blood donor acceptability with PDT strategy in the reduction of HBV risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A quasi\u2010experimental study was conducted with two groups of participants. The consenting subjects chose prospectively and randomly either the PDS or the current PDT strategy. The donors included in the PDS group were screened for hepatitis B surface antigen (HBsAg) by using a World Health Organization (WHO)\u2010prequalified HBsAg assay. The PDT strategy consisted of the routine double HBsAg testing with a combination of a rapid diagnostic test (RDT) and enzyme immuno assay (EIA). HBV confirmatory strategy combined testing for DNA detection and HBsAg neutralization assay. A questionnaire was designed to assess donor and staff satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2528 blood donors were included in the study, of whom 1146 and 1382 went through PDS and PDT screening, respectively. The sensitivity of PDS and PDT was 100% and 96.4% (95% confidence interval [CI]: 93.1\u2013100), respectively, and the specificity was 99.9% (95% CI: 99.3\u2013100) for the two screening strategies. The overall acceptability score of the donor in the PDS group was 8.16\u2009\u00b1\u20091.61 versus 8.00\u2009\u00b1\u20091.55 in the PDT group (odds ratio [OR] 95% CI: 0.16 (0.04\u20130.28); <jats:italic>p<\/jats:italic>\u2009=\u20090.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study supports the benefits of safety and acceptability of the donor and also possible acceptable cost\/benefit of the screening measure in the case of limited resources.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.70058","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T02:06:12Z","timestamp":1749002772000},"page":"812-819","source":"Crossref","is-referenced-by-count":0,"title":["Performance and acceptability of pre\u2010donation screening and post\u2010donation testing for hepatitis B infection in a resource\u2010limited blood service"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-3105","authenticated-orcid":false,"given":"Claude","family":"Tayou Tagny","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biseuleu","family":"Loic","sequence":"additional","affiliation":[{"name":"Division of Laboratory Sciences Institut Sup\u00e9rieur de Technologie M\u00e9dicale  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Ndemanou","sequence":"additional","affiliation":[{"name":"Centre National de Transfusion Sanguine  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fopa","family":"Diderot","sequence":"additional","affiliation":[{"name":"Centre Hospitalier et Universitaire de Yaound\u00e9  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5191-4326","authenticated-orcid":false,"given":"Claude","family":"Maugard","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Candotti","sequence":"additional","affiliation":[{"name":"Department of Virology Mondor Institute of Biomedical Research  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"Nguefack\u2010Tsague","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 1  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6497-0108","authenticated-orcid":false,"given":"Syria","family":"Laperche","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2012.08.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01697.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02137.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2009.00958.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12702"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12809"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.04279.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/npmj.npmj_33_17"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4314\/gmj.v48i3.7"},{"volume-title":"Screening donated blood for 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