{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:07:36Z","timestamp":1767892056483,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>After several years of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) circulation in the Netherlands, most individuals acquired the infection. However, an unknown number of uninfected persons could still be solely dependent on vaccination for protection. In this study, we aimed to retrospectively quantify the proportion of blood donors, without signs of prior SARS\u2010CoV\u20102 infection, who acquired SARS\u2010CoV\u20102 infection after August 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Based on data collected in previous SARS\u2010CoV\u20102 serosurveillance studies, we created a cohort of donors who tested negative for anti\u2010nucleocapsid (NC) antibodies between August 2022 and September 2023. If these donors donated blood during the follow\u2010up period, between 1 October 2023 and 12 September 2024, their donation was again tested for anti\u2010NC to see whether they seroconverted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 992 donors whose donation(s) tested negative for anti\u2010NC between August 2022 and September 2023, 824 (83%) donated during the follow\u2010up period. Older donors were overrepresented in the study. Of the included donors, 67% seroconverted for anti\u2010NC after August 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of Dutch blood donors who were still uninfected acquired primary infection after August 2022, coinciding with the circulation of SARS\u2010CoV\u20102 omicron variants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.70077","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:20:31Z","timestamp":1754266831000},"page":"1034-1037","source":"Crossref","is-referenced-by-count":1,"title":["<scp>SARS<\/scp>\u2010<scp>CoV<\/scp>\u20102 infection after August 2022 in Dutch blood donors without serological signs of prior infection"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-9254","authenticated-orcid":false,"given":"Franke A.","family":"Quee","sequence":"first","affiliation":[{"name":"Donor Studies, Department of Research Sanquin Blood Supply Foundation  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Hogema","sequence":"additional","affiliation":[{"name":"Blood\u2010Borne Infections, Department of Research Sanquin Blood Supply Foundation  Amsterdam the Netherlands"},{"name":"Department of Virology Sanquin Diagnostic Services  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Slot","sequence":"additional","affiliation":[{"name":"Blood\u2010Borne Infections, Department of Research Sanquin Blood Supply Foundation  Amsterdam the Netherlands"},{"name":"Department of Medical Affairs Sanquin Blood Supply Foundation  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3241-6003","authenticated-orcid":false,"given":"K.","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Donor Studies, Department of Research Sanquin Blood Supply Foundation  Amsterdam the Netherlands"},{"name":"Department of Public and Occupational Health Amsterdam Public Health Research Institute, Amsterdam UMC  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. L.","family":"Zaaijer","sequence":"additional","affiliation":[{"name":"Blood\u2010Borne Infections, Department of Research Sanquin Blood Supply Foundation  Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2023.05.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08448-w"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13312"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2023.2222849"},{"key":"e_1_2_9_6_1","article-title":"Anti\u2010SARS\u2010CoV\u20102 IgG seroprevalence in Tyrol, Austria, among 28,768 blood donors between May 2022 and March 2023","volume":"12","author":"Siller A","year":"2024","journal-title":"Vaccine"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2021.26.43.2100830"},{"key":"e_1_2_9_8_1","unstructured":"RIVM.Timeline Infection Preventive Measures.2022. Available from:https:\/\/www.rivm.nl\/gedragsonderzoek\/tijdlijn\u2010maatregelen\u2010covid. Last accessed 17 Jun 2025."},{"key":"e_1_2_9_9_1","unstructured":"Bloedvoorziening SS. Sanquin Jaarverslag.2022. Available from:https:\/\/www.sanquin.nl\/over-sanquin\/jaarverslagen. Last accessed 17 Jun 2025."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0305613"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2803.211885"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.70077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:39:24Z","timestamp":1760078364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.70077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,3]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/vox.70077"],"URL":"https:\/\/doi.org\/10.1111\/vox.70077","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,3]]}}}