{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:49:57Z","timestamp":1775854197868,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Blood donor selection is crucial for ensuring safe blood supply. A well\u2010designed donor selection system helps in maintaining donor engagement by minimizing unnecessary exclusion while safeguarding transfusion safety. We aimed to assess the risk of transfusion\u2010transmitted infections (TTIs) among high\u2010risk deferred donors to evaluate deferral criteria efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study included data from volunteers who were temporarily deferred because of bloodletting, high\u2010risk sexual contact, tattooing, endoscopy and needle sticks, as well as from eligible donors who donated blood over a 12\u2010month period. These donors were followed up for 4\u2009years. The results of infectious confirmatory tests, including hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV), of returned donors who donated blood were extracted from the database. Risk ratio (RR) of TTI was calculated to compare the risk between eligible and deferred donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data from 601,177 returned, deferred and eligible blood donors were analysed. The risk of TTIs was significantly higher in the deferred group compared to eligible donor group (RR: 3.58; 95% confidence interval [CI]: 2.68\u20134.80; <jats:italic>p<\/jats:italic>\u2009&lt;0.001). The risk of TTIs was significantly higher in those deferred for bloodletting (RR\u2009=\u20094.85; 95% CI: 3.41\u20136.91; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), tattooing (RR\u2009=\u20093.53; 95% CI: 1.26\u20133.83; <jats:italic>p<\/jats:italic>\u2009=\u20090.029) and high\u2010risk sexual contact (RR\u2009=\u20092.19; 95% CI: 1.26\u20133.83; <jats:italic>p<\/jats:italic>\u2009=\u20090.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with a history of bloodletting, tattooing or high\u2010risk sexual contact were at a higher risk of HBV and HCV infection, highlighting the effectiveness of donor selection procedures. Endoscopy and needle stick injuries were not associated with an increased TTI risk, emphasizing the need for further research to reassess these deferral criteria. Blood centres should monitor the efficacy of donor selection criteria while emphasizing proper donor selection and counselling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.70080","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:47:57Z","timestamp":1753058877000},"page":"987-994","source":"Crossref","is-referenced-by-count":1,"title":["Risk of transfusion\u2010transmitted infections among returned high\u2010risk deferred donors: A cohort study"],"prefix":"10.1111","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-1314","authenticated-orcid":false,"given":"Amir","family":"Teimourpour","sequence":"first","affiliation":[{"name":"Biological Products and Blood Safety Research Center, High Institute for Research and Education in Transfusion Medicine  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-4635","authenticated-orcid":false,"given":"Sedigheh","family":"Amini\u2010Kafiabad","sequence":"additional","affiliation":[{"name":"Biological Products and Blood Safety Research Center, High Institute for Research and Education in Transfusion Medicine  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2699-8706","authenticated-orcid":false,"given":"Amir Masoud","family":"Nazemi","sequence":"additional","affiliation":[{"name":"Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2789","authenticated-orcid":false,"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Epidemiology and Surveillance, Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-8354","authenticated-orcid":false,"given":"Mahtab","family":"Maghsudlu","sequence":"additional","affiliation":[{"name":"Biological Products and Blood Safety Research Center, High Institute for Research and Education in Transfusion Medicine  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.01008.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2005.00577.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/hepatmon.109451"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.03.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15404"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2008.0238"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2156587214524578"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2024.04.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15409"},{"key":"e_1_2_9_11_1","article-title":"Update on transmission modes of hepatitis 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