{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:31Z","timestamp":1787016091868,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Population study on immunogenetic polymorphism of human platelet antigens (HPAs) may aid in predicting the risk of alloimmune thrombocytopaenia syndromes. We aimed to characterize the diversity of HPAs in Saudis and estimate the alloimmunization risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We assessed the genotype and allele frequencies of HPA\u20101 to \u201011 and HPA\u201015 in 118 Saudi blood donors using a real\u2010time polymerase chain reaction assay. We estimated the mismatch risk associated with blood transfusions and pregnancies for each individual allele. Furthermore, we evaluated the mismatch risk for various haplotypes constructed from all HPA genes, as well as focusing on the highly immunogenic HPA\u20101 and \u20105 systems. Moreover, our data were integrated with data from other populations to perform principal component analysis (PCA) and phylogenetic analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequencies of the \u2018a\u2019 and \u2018b\u2019 alleles for the polymorphic HPA\u20101, \u20102, \u20103, \u20105 and \u201015 genes were as follows: HPA\u20101a\/b: 0.831\/0.169; HPA\u20102a\/b: 0.856\/0.144; HPA\u20103a\/b: 0.729\/0.271; HPA\u20105a\/b: 0.822\/0.178 and HPA\u201015a\/b: 0.449\/0.561. A slight polymorphism was observed in HPA\u20109: 0.992\/0.008. The HPA\u20104, \u20106, \u20107, 8, \u201010 and \u201011 genes were found monomorphic. We found 54 different concatenated haplotypes; the mismatch probability of each varied between 0.85% and 11.72%. The PCA indicated a significant non\u2010random grouping of populations into four genetically distinct clusters. This pattern is confirmed by the neighbour\u2010joining phylogenetic tree.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study is useful for HPA immunogenetics and offers a database for further research on transfusion medicine, alloimmune thrombocytopaenia as well as on population genetics in the Arabian Peninsula and beyond.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.70093","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T01:57:06Z","timestamp":1756173426000},"page":"1025-1033","source":"Crossref","is-referenced-by-count":1,"title":["Immunogenetic polymorphism of human platelet antigens in the Saudi population: Insights into genetic diversity and alloimmune risk"],"prefix":"10.1111","volume":"120","author":[{"given":"Omar","family":"AlSuhaibani","sequence":"first","affiliation":[{"name":"Immunology and Histocompatibility Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"},{"name":"Hematology and Blood Bank Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Chatti","sequence":"additional","affiliation":[{"name":"Genomics, Biotechnology and Anti\u2010Viral Strategies UR17ES30, USCR\u2010SAG, Sequencing and Genomic Analysis, Higher Institute of Biotechnology, University of Monastir  Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"AlZahrani","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"AlHajuj","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalel","family":"Malhani","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"AlDosseri","sequence":"additional","affiliation":[{"name":"Hematology and Blood Bank Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassim","family":"Albasri","sequence":"additional","affiliation":[{"name":"Hematology and Blood Bank Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghaleb","family":"Elyamany","sequence":"additional","affiliation":[{"name":"Hematology and Blood Bank Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0536-4440","authenticated-orcid":false,"given":"Hadef","family":"Skouri","sequence":"additional","affiliation":[{"name":"Immunology and Histocompatibility Laboratory, CML &amp; BB Department Prince Sultan Military Medical City (PSMMC)  Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/labmed-2020-0012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/aob-21-47"},{"key":"e_1_2_9_4_1","unstructured":"Versiti.Human Platelet Antigen (HPA) Database. 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